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Chemical Compound Review

Sabrilex     4-aminohex-5-enoic acid

Synonyms: Sabril, vigabatrin, gamma-Vinyl-GABA, gamma Vinyl GABA, Vigabatrin Aventis Brand, ...
 
 
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Disease relevance of Sabril

 

Psychiatry related information on Sabril

 

High impact information on Sabril

 

Chemical compound and disease context of Sabril

 

Biological context of Sabril

 

Anatomical context of Sabril

 

Associations of Sabril with other chemical compounds

 

Gene context of Sabril

 

Analytical, diagnostic and therapeutic context of Sabril

References

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  23. Monitoring of 4-hydroxybutyric acid levels in body fluids during vigabatrin treatment in succinic semialdehyde dehydrogenase deficiency. Ergezinger, K., Jeschke, R., Frauendienst-Egger, G., Korall, H., Gibson, K.M., Schuster, V.H. Ann. Neurol. (2003) [Pubmed]
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  26. Human brain GABA levels rise after initiation of vigabatrin therapy but fail to rise further with increasing dose. Petroff, O.A., Rothman, D.L., Behar, K.L., Mattson, R.H. Neurology (1996) [Pubmed]
  27. Vigabatrin increases human brain homocarnosine and improves seizure control. Petroff, O.A., Mattson, R.H., Behar, K.L., Hyder, F., Rothman, D.L. Ann. Neurol. (1998) [Pubmed]
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  31. Vigabatrin transport across the human intestinal epithelial (Caco-2) brush-border membrane is via the H(+)-coupled amino-acid transporter hPAT1. Abbot, E.L., Grenade, D.S., Kennedy, D.J., Gatfield, K.M., Thwaites, D.T. Br. J. Pharmacol. (2006) [Pubmed]
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  34. Effect of vigabatrin on glutamate dehydrogenase in the hippocampus of seizure prone gerbils. Kang, T.C., An, S.J., Park, S.K., Hwang, I.K., Choi, S.Y., Kwon, O.S., Won, M.H. Neurosci. Lett. (2003) [Pubmed]
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  36. Outer retinal dysfunction in patients treated with vigabatrin. Arndt, C.F., Derambure, P., Defoort-Dhellemmes, S., Hache, J.C. Neurology (1999) [Pubmed]
 
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