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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Calcium and myokymia of brainstem origin.

In five patients with Guillain-Barré syndrome, clinical myokymia increased and myokymic burst amplification occurred when ionized Ca++ was lowered by hyperventilation. Myokymia decreased when ionized Ca++ was increased after IV infusion of CaCl2. These responses were absent or diminished in the four patients with myokymia due to brainstem lesions, suggesting that the blood-brain barrier impedes the effects of altered serum ionized Ca++ on axonal excitability. Altering serum Ca++ can distinguish peripheral and central myokymia.[1]


  1. Calcium and myokymia of brainstem origin. Gutmann, L., Brick, J.F., Riggs, J.E. Neurology (1986) [Pubmed]
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