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MeSH Review


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Disease relevance of Hyperventilation


Psychiatry related information on Hyperventilation


High impact information on Hyperventilation


Chemical compound and disease context of Hyperventilation


Biological context of Hyperventilation

  • Before receiving lactate, patients showed higher heart rates than controls and also signs of hyperventilation [19].
  • Following CO2 or hyperventilation challenges, respiratory rate dropped sharply, while tidal volume remained elevated longer in patients than in comparison subjects [20].
  • Patients who were vulnerable to lactate-induced panic had several abnormalities in the resting, nonpanic state: an abnormal hemispheric asymmetry of parahippocampal blood flow, blood volume, and oxygen metabolism; abnormally high whole brain metabolism; and abnormal susceptibility to episodic hyperventilation [21].
  • It is concluded that intravenous administration of adenosine produces marked cerebral vasodilation in normoventilated subjects and that this response can be counteracted by hyperventilation [22].
  • As the prevailing rate of reaction of oxygen with cytochrome c oxidase is linked to the tension of oxygen, the claim fails to explain how oxygen consumption is maintained during moderate reductions of CBF imposed by hyperventilation (hypocapnia) or cyclooxygenase (COX) inhibition [23].

Anatomical context of Hyperventilation


Gene context of Hyperventilation

  • Thus SP-A is necessary for lungs to respond to hyperventilation or secretagogues with increased DPPC uptake and also modulates the PLA(2)-mediated degradation of internalized DPPC [29].
  • Voluntary hyperventilation prolonged BHT and increased Delta P ACO2 [30].
  • METHODS: IC and FEV(1) were measured before and after metronome-paced hyperventilation at twice the resting respiratory rate for 20 s in 16 patients with COPD before and after 54 microg aerosolized ipratropium bromide (IB) [31].
  • Despite comparable basal PTH values, the patients with hypoparathyroidism and the normocalcaemic patients, with tetany following thyroid surgery, responded less than normals to EDTA, while normocalcaemic patients with tetany due to psychogenic hyperventilation responded more than normals [32].
  • In a separate group of 3 subjects, superimposition of hyperventilation during highlevel LBNP caused a further decrease in VMCA (31 +/- 7%) but no change in BP or level of consciousness [33].

Analytical, diagnostic and therapeutic context of Hyperventilation


  1. Pulmonary arteriovenous malformations. Physiologic observations and results of therapeutic balloon embolization. Terry, P.B., White, R.I., Barth, K.H., Kaufman, S.L., Mitchell, S.E. N. Engl. J. Med. (1983) [Pubmed]
  2. The hyperventilation of cirrhosis: progesterone and estradiol effects. Lustik, S.J., Chhibber, A.K., Kolano, J.W., Hilmi, I.A., Henson, L.C., Morris, M.C., Bronsther, O. Hepatology (1997) [Pubmed]
  3. Intracranial hypertension in acute liver failure: pathophysiological basis of rational management. Jalan, R. Semin. Liver Dis. (2003) [Pubmed]
  4. Nortriptyline-induced severe hyperventilation. Sunderrajan, S., Brooks, C.S., Sunderrajan, E.V. Arch. Intern. Med. (1985) [Pubmed]
  5. Assessment of nitric oxide formation during exercise. St Croix, C.M., Wetter, T.J., Pegelow, D.F., Meyer, K.C., Dempsey, J.A. Am. J. Respir. Crit. Care Med. (1999) [Pubmed]
  6. Proton magnetic resonance spectroscopy investigation of hyperventilation in subjects with panic disorder and comparison subjects. Dager, S.R., Strauss, W.L., Marro, K.I., Richards, T.L., Metzger, G.D., Artru, A.A. The American journal of psychiatry. (1995) [Pubmed]
  7. Response to hyperventilation and 5.5% CO2 inhalation of subjects with types of specific phobia, panic disorder, or no mental disorder. Antony, M.M., Brown, T.A., Barlow, D.H. The American journal of psychiatry. (1997) [Pubmed]
  8. Hypocapnia decreases the amount of rapid eye movement sleep in cats. Lovering, A.T., Fraigne, J.J., Dunin-Barkowski, W.L., Vidruk, E.H., Orem, J.M. Sleep. (2003) [Pubmed]
  9. Hyperventilation and anxiety in panic disorder, social phobia, GAD and normal controls. Holt, P.E., Andrews, G. Behaviour research and therapy. (1989) [Pubmed]
  10. Serotonin and the control of ventilation in awake rats. Olson, E.B., Dempsey, J.A., McCrimmon, D.R. J. Clin. Invest. (1979) [Pubmed]
  11. The effect of hyperventilation on distal nephron hydrogen ion secretion. Giammarco, R.A., Goldstein, M.B., Halperin, M.L., Stinebaugh, B.J. J. Clin. Invest. (1976) [Pubmed]
  12. Cerebral metabolism of ammonia and amino acids in patients with fulminant hepatic failure. Strauss, G.I., Knudsen, G.M., Kondrup, J., Møller, K., Larsen, F.S. Gastroenterology (2001) [Pubmed]
  13. Death associated with hyperventilation. Bouras, N., Kartsouris, L.D., Bridges, P.K. Lancet (1987) [Pubmed]
  14. Controlled study of respiratory responses during prolonged measurement in patients with chronic hyperventilation. Gardner, W.N., Meah, M.S., Bass, C. Lancet (1986) [Pubmed]
  15. Salicylate-induced hyperventilation. Ring, T., Andersen, P.T., Knudsen, F., Nielsen, F.B. Lancet (1985) [Pubmed]
  16. Blood gas changes and hypophosphatemia in lactate-induced panic. Gorman, J.M., Cohen, B.S., Liebowitz, M.R., Fyer, A.J., Ross, D., Davies, S.O., Klein, D.F. Arch. Gen. Psychiatry (1986) [Pubmed]
  17. Carbon monoxide poisoning presenting as hyperventilation syndrome. Skorodin, M.S., King, F., Sharp, J.T. Ann. Intern. Med. (1986) [Pubmed]
  18. Impairment of myocardial O2 supply due to hyperventilation. Neill, W.A., Hattenhauer, M. Circulation (1975) [Pubmed]
  19. Lactate provocation of panic attacks. II. Biochemical and physiological findings. Liebowitz, M.R., Gorman, J.M., Fyer, A.J., Levitt, M., Dillon, D., Levy, G., Appleby, I.L., Anderson, S., Palij, M., Davies, S.O. Arch. Gen. Psychiatry (1985) [Pubmed]
  20. Respiratory psychophysiology of panic disorder: three respiratory challenges in 98 subjects. Papp, L.A., Martinez, J.M., Klein, D.F., Coplan, J.D., Norman, R.G., Cole, R., de Jesus, M.J., Ross, D., Goetz, R., Gorman, J.M. The American journal of psychiatry. (1997) [Pubmed]
  21. The application of positron emission tomography to the study of panic disorder. Reiman, E.M., Raichle, M.E., Robins, E., Butler, F.K., Herscovitch, P., Fox, P., Perlmutter, J. The American journal of psychiatry. (1986) [Pubmed]
  22. Effect of adenosine on human cerebral blood flow as determined by positron emission tomography. Sollevi, A., Ericson, K., Eriksson, L., Lindqvist, C., Lagerkranser, M., Stone-Elander, S. J. Cereb. Blood Flow Metab. (1987) [Pubmed]
  23. Cerebral metabolic response to low blood flow: possible role of cytochrome oxidase inhibition. Gjedde, A., Johannsen, P., Cold, G.E., Ostergaard, L. J. Cereb. Blood Flow Metab. (2005) [Pubmed]
  24. Response of ventilation and of intracranial pressure during rebreathing of carbon dioxide in patients with acute brain damage. North, J.B., Jennett, S. Brain (1976) [Pubmed]
  25. Cerebral effects of extended hyperventilation in unanesthetized goats. Albrecht, R.F., Miletich, D.J., Ruttle, M. Stroke (1987) [Pubmed]
  26. Regional blood flow in canine brain during nicotine infusion: pentobarbital vs. chloralose anesthesia. Bedran de Castro, M.T., Crystal, G.J., Downey, H.F., Bashour, F.A. Stroke (1984) [Pubmed]
  27. Pseudo-steroid resistant asthma. Thomas, P.S., Geddes, D.M., Barnes, P.J. Thorax (1999) [Pubmed]
  28. Changes in carotid body amine levels and effects of dopamine on respiration in rats treated neonatally with capsaicin. McQueen, D.S., Mir, A.K. Br. J. Pharmacol. (1984) [Pubmed]
  29. SP-A is necessary for increased clearance of alveolar DPPC with hyperventilation or secretagogues. Jain, D., Dodia, C., Bates, S.R., Hawgood, S., Poulain, F.R., Fisher, A.B. Am. J. Physiol. Lung Cell Mol. Physiol. (2003) [Pubmed]
  30. Voluntary breath-holding in the morning and in the evening. Bosco, G., Ionadi, A., Data, P.G., Mortola, J.P. Clin. Sci. (2004) [Pubmed]
  31. Simplified detection of dynamic hyperinflation. Gelb, A.F., Gutierrez, C.A., Weisman, I.M., Newsom, R., Taylor, C.F., Zamel, N. Chest (2004) [Pubmed]
  32. Parathyroid response to EDTA in hypoparathyroidism and in tetany. Burckhardt, P., Tscholl-Ducommun, J., Ruedi, B. Acta Endocrinol. (1980) [Pubmed]
  33. Cerebral versus systemic hemodynamics during graded orthostatic stress in humans. Levine, B.D., Giller, C.A., Lane, L.D., Buckey, J.C., Blomqvist, C.G. Circulation (1994) [Pubmed]
  34. Blockade of ATP-sensitive potassium channels in cerebral arterioles inhibits vasoconstriction from hypocapnic alkalosis in cats. Wei, E.P., Kontos, H.A. Stroke (1999) [Pubmed]
  35. Analysis of T-cell activation after bronchial allergen challenge in patients with atopic asthma. Lara-Marquez, M.L., Deykin, A., Krinzman, S., Listman, J., Israel, E., He, H., Christiani, D.C., Perkins, D.L., Finn, P.W. J. Allergy Clin. Immunol. (1998) [Pubmed]
  36. Hyperventilation technetium-99m-HMPAO brain SPECT in moyamoya disease to assess risk of natural childbirth. Kume, N., Hayashida, K., Shimotsu, Y., Matsunaga, N. J. Nucl. Med. (1997) [Pubmed]
  37. Circulating catecholamines in exercise and hyperventilation induced asthma. Barnes, P.J., Brown, M.J., Silverman, M., Dollery, C.T. Thorax (1981) [Pubmed]
  38. Activity of tyrosine hydroxylase in the striatum of newborn piglets in response to hypocapnic hypoxia. Tammela, O., Pastuszko, A., Lajevardi, N.S., Delivoria-Papadopoulos, M., Wilson, D.F. J. Neurochem. (1993) [Pubmed]
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