Inhibition of palmitoylcarnitine oxidation by pyruvate in rat heart mitochondria.
The oxidation of 1-14C-palmitoylcarnitine by rat heart mitochondria has been measured by assessing both the disappearance of substrate and the appearance of labelled products. Pyruvate inhibited palmitoylcarnitine oxidation by about 40%. Fifty percent inhibition occurred at about 20 mumol/L pyruvate. The inhibitory effect of pyruvate required entry of pyruvate into mitochondria since it did not occur in the presence of alpha-cyano-4-hydroxycinnamic acid, an inhibitor of the mitochondrial pyruvate transporter. The inhibitory effect of pyruvate also required an active pyruvate dehydrogenase. These studies indicate a mechanism that may be important in the replacement of fatty acids by carbohydrate as fuels of respiration of the heart during the transition from the starved to the fed state.[1]References
- Inhibition of palmitoylcarnitine oxidation by pyruvate in rat heart mitochondria. Brosnan, J.T., Reid, K. Metab. Clin. Exp. (1985) [Pubmed]
Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg