Effect of nicotine and N'-nitrosonornicotine on rat lung and trachea ornithine decarboxylase activity.
The exposure of rats to tobacco smoke was previously reported to cause an increase in lung and trachea ornithine decarboxylase ( ODC) activity. In the present paper we test the effects of the tobacco-specific components nicotine and N'-nitrosonornicotine (NNN) on lung and trachea ODC activity. In addition, a procedure for the synthesis of analytically pure NNN is described. NNN caused an increase in lung ODC activity 6 h and also 4 days after a single s.c. dose. NNN did not alter trachea ODC activity. A single s.c. dose of nicotine activated both lung and trachea ODC in a dose-response fashion. It is possible that the impact of these tobacco-specific agents upon respiratory tract polyamine biosynthesis could contribute to some of the multi-faceted effects associated with cigarette smoking.[1]References
- Effect of nicotine and N'-nitrosonornicotine on rat lung and trachea ornithine decarboxylase activity. Olson, J.W., Crooks, P.A. Carcinogenesis (1985) [Pubmed]
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