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Gene Review

Odc1  -  ornithine decarboxylase 1

Rattus norvegicus

Synonyms: ODC, Odc, Ornithine decarboxylase
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Disease relevance of Odc1


Psychiatry related information on Odc1

  • Induction of adrenal ODC following the stress of immobilization is already observed in the rat at 4 days of age but the induction caused by maternal deprivation or cold exposure is obtained only at 17 days [5].
  • To investigate the critical period over which dihydropyridines might be effective, their action at the earlier time point of 4 hours was tested where a significant induction of ornithine decarboxylase occurs (60 pmol/mg/hr).(ABSTRACT TRUNCATED AT 250 WORDS)[6]
  • However, the hippocampal ODC mRNA level was not increased by electroconvulsive shock [7].
  • We examined the influence, in autopsied human brain, of postnatal development and aging, regional distribution, and Alzheimer's disease on the activity of ornithine decarboxylase [8].
  • Since this starvation-refeeding regimen is quite similar to the "starve and gorge" feeding pattern exhibited by pair-fed control animals, the use of pair-fed controls may not be appropriate for examining either ODC levels or processes, such as tumor promotion, which may be linked to ODC levels [9].

High impact information on Odc1

  • Expression of ornithine decarboxylase antisense RNA was associated with an epithelioid morphology and reduced cell proliferation [10].
  • Our results imply that the gene encoding ornithine decarboxylase is a proto-oncogene central for regulation of cell growth and transformation [10].
  • The recently discovered class of tumour promoters, the teleocidins, are as potent as TPA in the induction of ornithine decarboxylase in mouse skin, the inhibition of differentiation of Friend erythroleukaemia cells, the induction of HL-60 cell adhesion and the promotion of tumours on mouse skin [11].
  • We report here that NGF-induced thirst and sodium appetite, as well as increased blood pressure and increase ornithine decarboxylase activity in the brain and liver, depend on the formation of AII (see also ref. 6) [12].
  • Spreading, differentiation, metabolism, DNA synthesis, expression of cell surface glycopeptides, deoxyglucose transport, as well as polyamine, plasminogen activator and ornithine decarboxylase activity are altered [13].

Chemical compound and disease context of Odc1


Biological context of Odc1


Anatomical context of Odc1


Associations of Odc1 with chemical compounds

  • It promoted DEN (N-diethyl nitrosamine) initiated renal carcinogenesis by increasing the percentage incidence of tumors and induces early tumor markers viz. ornithine decarboxylase (ODC) and renal DNA synthesis [1].
  • The current studies examine the temporal profile of renal ODC protein expression and localization, intrarenal polyamine levels, and sites of proliferation in kidneys of rats during the first 7 days of streptozotocin diabetes [2].
  • ODC activity increased in DEGBG-treated cells, despite high intracellular putrescine levels [22].
  • High putrescine levels in DEGBG-treated cells did not induce ODC antizyme when intracellular spermidine and spermine levels were low [22].
  • Although exogenous spermidine and spermine reduced ODC activity of DEGBG-treated cells close to control levels, spermine was more effective than spermidine [22].

Physical interactions of Odc1


Regulatory relationships of Odc1


Other interactions of Odc1


Analytical, diagnostic and therapeutic context of Odc1


  1. Modulatory effects of shape pluchea lanceolata against chemically induced oxidative damage, hyperproliferation and two-stage renal carcinogenesis in wistar rats. Jahangir, T., Sultana, S. Mol. Cell. Biochem. (2006) [Pubmed]
  2. Increased expression of ornithine decarboxylase in distal tubules of early diabetic rat kidneys: are polyamines paracrine hypertrophic factors? Deng, A., Munger, K.A., Valdivielso, J.M., Satriano, J., Lortie, M., Blantz, R.C., Thomson, S.C. Diabetes (2003) [Pubmed]
  3. Role of pyridoxal phosphate in mammalian polyamine biosynthesis. Lack of requirement for mammalian S-adenosylmethionine decarboxylase activity. Pegg, A.E. Biochem. J. (1977) [Pubmed]
  4. The translation in vitro of rat ornithine decarboxylase mRNA is blocked by its 5' untranslated region in a polyamine-independent way. Van Steeg, H., Van Oostrom, C.T., Hodemaekers, H.M., Peters, L., Thomas, A.A. Biochem. J. (1991) [Pubmed]
  5. Developmental pattern of ornithine decarboxylase activity, S-adenosylmethionine decarboxylase, and polyamines of rat adrenal glands. Ekker, M., Sourkes, T.L. Biol. Neonate (1987) [Pubmed]
  6. Reversal of neurotoxin-induced ornithine decarboxylase activity in rat cerebral cortex by nimodipine. A potential neuroprotective mechanism. Gardiner, I.M., de Belleroche, J. Stroke (1990) [Pubmed]
  7. Transcription-dependent and -independent induction of cerebral ornithine decarboxylase. Zawia, N.H., Bondy, S.C. J. Neurochem. (1992) [Pubmed]
  8. Ornithine decarboxylase in human brain: influence of aging, regional distribution, and Alzheimer's disease. Morrison, L.D., Cao, X.C., Kish, S.J. J. Neurochem. (1998) [Pubmed]
  9. Ornithine decarboxylase induction in rat colon: synergistic effects of intrarectal instillation of sodium deoxycholate and starvation-refeeding. Stanley, B.A., Kazarinoff, M.N. J. Nutr. (1984) [Pubmed]
  10. Ornithine decarboxylase activity is critical for cell transformation. Auvinen, M., Paasinen, A., Andersson, L.C., Hölttä, E. Nature (1992) [Pubmed]
  11. Similarity of teleocidin B and phorbol ester tumour promoters in effects on membrane receptors. Umezawa, K., Weinstein, I.B., Horowitz, A., Fujiki, H., Matsushima, T., Sugimura, T. Nature (1981) [Pubmed]
  12. Renin-like effects of NGF evaluated using renin-angiotensin antagonists. Avrith, D.B., Lewis, M.E., Fitzsimons, J.T. Nature (1980) [Pubmed]
  13. Suppression of natural antitumour defence mechanisms by phorbol esters. Keller, R. Nature (1979) [Pubmed]
  14. Sepsis increases putrescine concentration and protein synthesis in mucosa of small intestine in rats. Noguchi, Y., Meyer, T., Tiao, G., Fischer, J.E., Hasselgren, P.O. Shock (1996) [Pubmed]
  15. Influence of sepsis and endotoxemia on polyamine metabolism in mucosa of small intestine in rats. Noguchi, Y., Meyer, T.A., Tiao, G., Ogle, C.K., Fischer, J.E., Hasselgren, P.O. Metab. Clin. Exp. (1996) [Pubmed]
  16. Distribution of polyamines and their biosynthetic enzymes in intestinal adaptation. Luk, G.D., Yang, P. Am. J. Physiol. (1988) [Pubmed]
  17. Regulatory interrelations between GABA and polyamines. II. Effect of GABA on ornithine decarboxylase and putrescine levels in cell culture. McCann, P.P., Hornsperger, J.M., Seiler, N. Neurochem. Res. (1979) [Pubmed]
  18. Rat ornithine decarboxylase gene. Nucleotide sequence, potential regulatory elements, and comparison to the mouse gene. Wen, L., Huang, J.K., Blackshear, P.J. J. Biol. Chem. (1989) [Pubmed]
  19. Comparison of androgen regulation of ornithine decarboxylase and S-adenosylmethionine decarboxylase gene expression in rodent kidney and accessory sex organs. Crozat, A., Palvimo, J.J., Julkunen, M., Jänne, O.A. Endocrinology (1992) [Pubmed]
  20. Dietary regulation of the activities of ornithine decarboxylase and S-adenosylmethionine decarboxylase in rats. Moore, P., Swendseid, M.E. J. Nutr. (1983) [Pubmed]
  21. Regulation of ornithine decarboxylase and polyamine import by hypoxia in pulmonary artery endothelial cells. Babal, P., Ruchko, M., Ault-Ziel, K., Cronenberg, L., Olson, J.W., Gillespie, M.N. Am. J. Physiol. Lung Cell Mol. Physiol. (2002) [Pubmed]
  22. Polyamine regulation of ornithine decarboxylase and its antizyme in intestinal epithelial cells. Yuan, Q., Ray, R.M., Viar, M.J., Johnson, L.R. Am. J. Physiol. Gastrointest. Liver Physiol. (2001) [Pubmed]
  23. Regulation of rat ornithine decarboxylase promoter activity by binding of transcription factor Sp1. Kumar, A.P., Mar, P.K., Zhao, B., Montgomery, R.L., Kang, D.C., Butler, A.P. J. Biol. Chem. (1995) [Pubmed]
  24. Decreased activity of adrenal S-adenosylmethionine decarboxylase in rats subjected to dopamine agonists, metabolic stress, or bodily immobilization. Ekker, M., Sourkes, T.L. Endocrinology (1987) [Pubmed]
  25. Regulation of the activity of ornithine decarboxylase and S-adenosylmethionine decarboxylase in mammary gland and liver of lactating rats. Effects of starvation, prolactin and insulin deficiency. Brosnan, M.E., Ilic, V., Williamson, D.H. Biochem. J. (1982) [Pubmed]
  26. Differential effects of FSH on the activities of S-adenosyl-L-methionine decarboxylase and ornithine decarboxylase in Rat sertoli cells. Shubhada, S., Tsai, Y.H. J. Androl. (1990) [Pubmed]
  27. Lorglumide and loxiglumide inhibit gastrin-stimulated DNA synthesis in a rat tumoral acinar pancreatic cell line (AR42J). Seva, C., Scemama, J.L., Bastié, M.J., Pradayrol, L., Vaysse, N. Cancer Res. (1990) [Pubmed]
  28. Changes in ovarian luteinizing hormone and follicle-stimulating hormone receptor content and in gonadotropin-induced ornithine decarboxylase activity during prepubertal and pubertal development of the female rat. White, S.S., Ojeda, S.R. Endocrinology (1981) [Pubmed]
  29. Possible role of glutathione depletion in the induction of rate-limiting enzymes involved in heme degradation and polyamine biosynthesis in the liver of rats. Oguro, T., Yoshida, T., Numazawa, S., Kuroiwa, Y. J. Pharmacobio-dyn. (1990) [Pubmed]
  30. Adenovirus type 5 induces progression of quiescent rat cells into S phase without polyamine accumulation. Cheetham, B.F., Shaw, D.C., Bellett, A.J. Mol. Cell. Biol. (1982) [Pubmed]
  31. Antitrypanosomal effects of polyamine biosynthesis inhibitors correlate with increases in Trypanosoma brucei brucei S-adenosyl-L-methionine. Byers, T.L., Bush, T.L., McCann, P.P., Bitonti, A.J. Biochem. J. (1991) [Pubmed]
  32. Ornithine decarboxylase and S-adenosylmethionine decarboxylase activity in the accessory sex organs of intact, castrated, and androgen-stimulated castrated rats. Fjösne, H.E., Strand, H., Ostensen, M.A., Sunde, A. Prostate (1988) [Pubmed]
  33. Cloning and nucleotide sequence of rat ornithine decarboxylase cDNA. van Kranen, H.J., van de Zande, L., van Kreijl, C.F., Bisschop, A., Wieringa, B. Gene (1987) [Pubmed]
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