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MeSH Review

Trachea

 
 
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Disease relevance of Trachea

 

High impact information on Trachea

  • CLCA proteins were discovered in bovine trachea and named for a calcium-dependent chloride conductance found in trachea and in other secretory epithelial tissues [6].
  • Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus [7].
  • These results indicate that Shh is required for the growth and differentiation of the oesophagus, trachea and lung, and suggest that mutations in SHH and its signalling components may be involved in foregut defects in humans [8].
  • Mutant mice lacking both Gli2 and Gli3 function did not form oesophagus, trachea and lung [7].
  • Immunofluorescence studies with these antibodies reveal that HMG-1 or components which immunologically cross-react with HMG-1 are present in the cytoplasm of Chinese hamster V-79, rat liver TR-12 and bovine trachea EBTr-NBL-4 cells [9].
 

Chemical compound and disease context of Trachea

 

Biological context of Trachea

 

Anatomical context of Trachea

 

Associations of Trachea with chemical compounds

 

Gene context of Trachea

  • Translational readthrough in the hdc mRNA generates a novel branching inhibitor in the drosophila trachea [29].
  • The wg gene helps to pattern the developing trachea but is not responsible for all Wnt functions there [15].
  • Similarly, addition of hypotonic PBS to mouse trachea in vivo decreased AQP5 within 1 h, an effect blocked by ruthenium red [30].
  • We have isolated embryonic recessive lethal jing mutations that display genetic interactions in the embryonic CNS midline and trachea, with mutations in the bHLH-PAS genes single-minded and trachealess, and their downstream target genes (slit and breathless) [31].
  • Finally, we detected significant levels of GRIK2 expression in prostate, kidney, trachea, and lung, raising the possibility that this gene may be protective against multiple tumor types [32].
 

Analytical, diagnostic and therapeutic context of Trachea

References

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  5. The putative heparin-specific N-acetylglucosaminyl N-Deacetylase/N-sulfotransferase also occurs in non-heparin-producing cells. Toma, L., Berninsone, P., Hirschberg, C.B. J. Biol. Chem. (1998) [Pubmed]
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  7. Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Motoyama, J., Liu, J., Mo, R., Ding, Q., Post, M., Hui, C.C. Nat. Genet. (1998) [Pubmed]
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  19. Bradykinin-evoked sensitization of airway sensory nerves: a mechanism for ACE-inhibitor cough. Fox, A.J., Lalloo, U.G., Belvisi, M.G., Bernareggi, M., Chung, K.F., Barnes, P.J. Nat. Med. (1996) [Pubmed]
  20. Cloning and functional analysis of human p51, which structurally and functionally resembles p53. Osada, M., Ohba, M., Kawahara, C., Ishioka, C., Kanamaru, R., Katoh, I., Ikawa, Y., Nimura, Y., Nakagawara, A., Obinata, M., Ikawa, S. Nat. Med. (1998) [Pubmed]
  21. Vasoactive intestinal peptide: a possible transmitter of nonadrenergic relaxation of guinea pig airways. Matsuzaki, Y., Hamasaki, Y., Said, S.I. Science (1980) [Pubmed]
  22. Tubulogenesis in Drosophila: a requirement for the trachealess gene product. Isaac, D.D., Andrew, D.J. Genes Dev. (1996) [Pubmed]
  23. Interferon gamma regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells. Iwamoto, I., Nakajima, H., Endo, H., Yoshida, S. J. Exp. Med. (1993) [Pubmed]
  24. Asbestos-induced epithelial changes in organ cultures of hamster trachea: inhibition by retinyl methyl ether. Mossman, B.T., Craighead, J.E., MacPherson, B.V. Science (1980) [Pubmed]
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  29. Translational readthrough in the hdc mRNA generates a novel branching inhibitor in the drosophila trachea. Steneberg, P., Englund, C., Kronhamn, J., Weaver, T.A., Samakovlis, C. Genes Dev. (1998) [Pubmed]
  30. Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions. Sidhaye, V.K., Güler, A.D., Schweitzer, K.S., D'Alessio, F., Caterina, M.J., King, L.S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
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