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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Effects of tabernanthine on calcium and catecholamine stimulated contractions of isolated vascular and cardiac muscle.

The Iboga alkaloid tabernanthine (80 microM) non-competitively antagonized contractions in both the rat aorta and mesenteric artery induced by cumulative additions of noradrenaline and calcium. Tabernanthine (8, 40 and 80 microM) antagonized the K+ depolarization-induced contractions of the aorta. Tabernanthine (80 microM) depressed the phasic component of contractions induced by a single maximal concentration (10 microM) of noradrenaline in Ca++ -free solution. Tabernanthine induced a negative inotropic effect in electrically stimulated myocardial tissue and a negative chronotropic effect in the perfused rat heart. Tabernanthine is a calcium entry blocker which also affects cellular calcium metabolism.[1]

References

  1. Effects of tabernanthine on calcium and catecholamine stimulated contractions of isolated vascular and cardiac muscle. Hajo-Tello, N., Dupont, C., Wepierre, J., Cohen, Y., Miller, R., Godfraind, T. Archives internationales de pharmacodynamie et de thérapie. (1985) [Pubmed]
 
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