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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Potent antidopaminergic activity of estradiol at the pituitary level on prolactin release.

Prior incubation of rat anterior pituitary cells with 17beta-estradiol led to an almost complete reversal of the inhibitory effect of two dopamine agonists, dihydroergocornine and RU 24213, on both basal prolactin release and thyrotropin releasing hormone- induced prolactin release. These experiments thus demonstrate a direct interference of dopamine action by a peripheral hormone. Prolactin secretion by pituitary cells in primary culture could possibly serve as an easily accessible model of a system under dopaminergic control.[1]

References

  1. Potent antidopaminergic activity of estradiol at the pituitary level on prolactin release. Raymond, V., Beaulieu, M., Labrie, F., Boissier, J. Science (1978) [Pubmed]
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