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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Optic atrophy after irrigation of the lacrimal ducts with chloramphenicol.

A case is presented of permanent visual loss and optic atrophy following irrigation of the lower canaliculus after probing, with a 20% solution of chloramphenicol. A false passage had apparently been created allowing the solution to gain access to the orbital tissues. The ensuing orbital edema probably caused a central retinal artery occlusion. This is a previously unreported complication of a common ophthalmologic procedure.[1]


  1. Optic atrophy after irrigation of the lacrimal ducts with chloramphenicol. Rothkoff, L., Biedner, B., Shoham, K., Blumenthal, M. Annals of ophthalmology. (1979) [Pubmed]
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