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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Refractory infantile diarrhea due to primary bile acid malabsorption.

A boy is described who had severe, refractory diarrhea beginning soon after birth. Prolonged parenteral alimentation was required to support life. Investigations of bile acid metabolism showed impaired intestinal absorption of bile acids. Contracted bile acid pool sizes resulted, with low intraluminal bile acid concentrations and severe, malabsorption of water and fat. Bile acid malabsorption is a cause of refractory infantile diarrhea.[1]


  1. Refractory infantile diarrhea due to primary bile acid malabsorption. Heubi, J.E., Balistreri, W.F., Partin, J.C., Schubert, W.K., McGraw, C.A. J. Pediatr. (1979) [Pubmed]
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