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Sloberg, K. et al.

Topical tretinoin therapy and oral lichen planus.

The treatment of severe forms of oral lichen planus is still relatively unsatisfactory. In this controlled study, 0.1% tretinoin in an adhesive base was used in 23 patients. Fifteen other control patients were similarly treated with the vehicle alone. In the tretinoin-treated group, 71% of the atrophic-erosive lesions improved while 29% improved from the vehicle (P less than .05). Reticular-plaque lesions improved in 74% from tretinoin and in 15% from the vehicle (P less than .001). Irritation from tretinoin occurs and thorough usage information is mandatory.[1]

References

Topical tretinoin therapy and oral lichen planus. Sloberg, K., Hersle, K., Mobacken, H., Thilander, H. Archives of dermatology. (1979) [Pubmed]

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