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Chemical Compound Review

Vesanoid     (2E,4E,6E,8E)-3,7-dimethyl-9- (2,6,6...

Synonyms: tretinoin, Retin-A, Retin A, Retinoic acid, Acid, Retinoic, ...
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Disease relevance of Retin-A


Psychiatry related information on Retin-A

  • In a previously reported study on the anti-photoageing effects of topical tretinoin, the following regimen produced good patient compliance: 0.01% for 1 month, 0.025% for 1 month; and 0.05% for 4 months [6].
  • Suppression of the forebrain genes has a narrow critical period of RA response during the early culture phase [7].

High impact information on Retin-A

  • We show that both PML and Tif1alpha are growth suppressors required for the growth-inhibitory activity of RA [8].
  • T18, similar to PML-RARalpha, disrupts the RA-dependent activity of this complex in a dominant-negative manner resulting in a growth advantage [8].
  • In Pml-/- cells, the RA-dependent induction of genes such as RARB2 and the ability of Tif1alpha and CBP to act as transcriptional coactivators on RA are impaired [8].
  • We also determined the effect of all-trans-retinoic acid on the expression of annexin II and the generation of cell-surface plasmin [1].
  • Here we show that PML, Tif1alpha and RXRalpha/RARalpha function together in a transcription complex that is dependent on retinoic acid (RA) [8].

Chemical compound and disease context of Retin-A


Biological context of Retin-A


Anatomical context of Retin-A


Associations of Retin-A with other chemical compounds


Gene context of Retin-A


Analytical, diagnostic and therapeutic context of Retin-A


  1. Annexin II and bleeding in acute promyelocytic leukemia. Menell, J.S., Cesarman, G.M., Jacovina, A.T., McLaughlin, M.A., Lev, E.A., Hajjar, K.A. N. Engl. J. Med. (1999) [Pubmed]
  2. Tretinoin for hyperpigmentation in black patients. LaVoo, E.J. N. Engl. J. Med. (1993) [Pubmed]
  3. Topical tretinoin (retinoic acid) therapy for hyperpigmented lesions caused by inflammation of the skin in black patients. Bulengo-Ransby, S.M., Griffiths, C.E., Kimbrough-Green, C.K., Finkel, L.J., Hamilton, T.A., Ellis, C.N., Voorhees, J.J. N. Engl. J. Med. (1993) [Pubmed]
  4. Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats. Massaro, G.D., Massaro, D. Nat. Med. (1997) [Pubmed]
  5. Regulation of the differentiation of teratocarcinoma cells into primitive endoderm by G alpha i2. Watkins, D.C., Johnson, G.L., Malbon, C.C. Science (1992) [Pubmed]
  6. Experience with tretinoin therapy in temperate regions. Caputo, R., Monti, M., Rigoni, C., Pinelli, S., Motta, S., Barbareschi, M. Br. J. Dermatol. (1992) [Pubmed]
  7. Distinct effects of caudalizing factors on regional specification of embryonic stem cell-derived neural precursors. Irioka, T., Watanabe, K., Mizusawa, H., Mizuseki, K., Sasai, Y. Brain Res. Dev. Brain Res. (2005) [Pubmed]
  8. A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins. Zhong, S., Delva, L., Rachez, C., Cenciarelli, C., Gandini, D., Zhang, H., Kalantry, S., Freedman, L.P., Pandolfi, P.P. Nat. Genet. (1999) [Pubmed]
  9. Apoptosis of N-type neuroblastoma cells after differentiation with 9-cis-retinoic acid and subsequent washout. Lovat, P.E., Irving, H., Annicchiarico-Petruzzelli, M., Bernassola, F., Malcolm, A.J., Pearson, A.D., Melino, G., Redfern, C.P. J. Natl. Cancer Inst. (1997) [Pubmed]
  10. Methylation and silencing of the retinoic acid receptor-beta2 gene in breast cancer. Widschwendter, M., Berger, J., Hermann, M., Müller, H.M., Amberger, A., Zeschnigk, M., Widschwendter, A., Abendstein, B., Zeimet, A.G., Daxenbichler, G., Marth, C. J. Natl. Cancer Inst. (2000) [Pubmed]
  11. Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid. Huang, C., Ma, W.Y., Dawson, M.I., Rincon, M., Flavell, R.A., Dong, Z. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  12. Retinol inhibits the growth of all-trans-retinoic acid-sensitive and all-trans-retinoic acid-resistant colon cancer cells through a retinoic acid receptor-independent mechanism. Park, E.Y., Dillard, A., Williams, E.A., Wilder, E.T., Pepper, M.R., Lane, M.A. Cancer Res. (2005) [Pubmed]
  13. Evaluation of vitamin A analogs in modulating epithelial differentiation of 13-day chick embryo metatarsal skin explants. Wilkoff, L.J., Peckham, J.C., Dulmadge, E.A., Mowry, R.W., Chopra, D.P. Cancer Res. (1976) [Pubmed]
  14. Suprabasal expression of a dominant-negative RXR alpha mutant in transgenic mouse epidermis impairs regulation of gene transcription and basal keratinocyte proliferation by RAR-selective retinoids. Feng, X., Peng, Z.H., Di, W., Li, X.Y., Rochette-Egly, C., Chambon, P., Voorhees, J.J., Xiao, J.H. Genes Dev. (1997) [Pubmed]
  15. Dose-dependent pharmacokinetics of all-trans-retinoic acid. Adamson, P.C., Balis, F.M., Smith, M.A., Murphy, R.F., Godwin, K.A., Poplack, D.G. J. Natl. Cancer Inst. (1992) [Pubmed]
  16. Cyclin D1 proteolysis: a retinoid chemoprevention signal in normal, immortalized, and transformed human bronchial epithelial cells. Boyle, J.O., Langenfeld, J., Lonardo, F., Sekula, D., Reczek, P., Rusch, V., Dawson, M.I., Dmitrovsky, E. J. Natl. Cancer Inst. (1999) [Pubmed]
  17. Variability in the oral bioavailability of all-trans-retinoic acid. Adamson, P.C., Pitot, H.C., Balis, F.M., Rubin, J., Murphy, R.F., Poplack, D.G. J. Natl. Cancer Inst. (1993) [Pubmed]
  18. Pathophysiology of premature skin aging induced by ultraviolet light. Fisher, G.J., Wang, Z.Q., Datta, S.C., Varani, J., Kang, S., Voorhees, J.J. N. Engl. J. Med. (1997) [Pubmed]
  19. Topical tretinoin (retinoic acid) treatment for liver spots associated with photodamage. Rafal, E.S., Griffiths, C.E., Ditre, C.M., Finkel, L.J., Hamilton, T.A., Ellis, C.N., Voorhees, J.J. N. Engl. J. Med. (1992) [Pubmed]
  20. Treatment of photoaged skin with topical tretinoin increases epidermal-dermal anchoring fibrils. A preliminary report. Woodley, D.T., Zelickson, A.S., Briggaman, R.A., Hamilton, T.A., Weiss, J.S., Ellis, C.N., Voorhees, J.J. JAMA (1990) [Pubmed]
  21. Variants of a human monocytic leukemia cell line (THP-1): induction of differentiation by retinoic acid, interferon-gamma, and T-lymphocyte-derived differentiation-inducing activity. Nakamura, T., Hemmi, H., Aso, H., Ishida, N. J. Natl. Cancer Inst. (1986) [Pubmed]
  22. Acute promyelocytic leukemia. Warrell, R.P., de Thé, H., Wang, Z.Y., Degos, L. N. Engl. J. Med. (1993) [Pubmed]
  23. All-trans-retinoic acid in acute promyelocytic leukemia. Tallman, M.S., Andersen, J.W., Schiffer, C.A., Appelbaum, F.R., Feusner, J.H., Ogden, A., Shepherd, L., Willman, C., Bloomfield, C.D., Rowe, J.M., Wiernik, P.H. N. Engl. J. Med. (1997) [Pubmed]
  24. Retinoic acid inhibits the regulated expression of vascular cell adhesion molecule-1 by cultured dermal microvascular endothelial cells. Gille, J., Paxton, L.L., Lawley, T.J., Caughman, S.W., Swerlick, R.A. J. Clin. Invest. (1997) [Pubmed]
  25. Retinoic acid-induced changes in 1 alpha,25-dihydroxyvitamin D3 receptor levels in tumor and nontumor cells derived from rat bone. Petkovich, P.M., Heersche, J.N., Aubin, J.E., Grigoriadis, A.E., Jones, G. J. Natl. Cancer Inst. (1987) [Pubmed]
  26. Cloning of a novel receptor expressed in rat prostate and ovary. Kuiper, G.G., Enmark, E., Pelto-Huikko, M., Nilsson, S., Gustafsson, J.A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  27. Anchorage-independent growth of synoviocytes from arthritic and normal joints. Stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-beta and retinoids. Lafyatis, R., Remmers, E.F., Roberts, A.B., Yocum, D.E., Sporn, M.B., Wilder, R.L. J. Clin. Invest. (1989) [Pubmed]
  28. Reexpression of retinoic acid receptor (RAR) gamma or overexpression of RAR alpha or RAR beta in RAR gamma-null F9 cells reveals a partial functional redundancy between the three RAR types. Taneja, R., Bouillet, P., Boylan, J.F., Gaub, M.P., Roy, B., Gudas, L.J., Chambon, P. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  29. Retinoids downregulate both p60 and p80 forms of tumor necrosis factor receptors in human histiocytic lymphoma U-937 cells. Totpal, K., Chaturvedi, M.M., LaPushin, R., Aggarwal, B.B. Blood (1995) [Pubmed]
  30. Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter. Benkoussa, M., Brand, C., Delmotte, M.H., Formstecher, P., Lefebvre, P. Mol. Cell. Biol. (2002) [Pubmed]
  31. PML colocalizes with and stabilizes the DNA damage response protein TopBP1. Xu, Z.X., Timanova-Atanasova, A., Zhao, R.X., Chang, K.S. Mol. Cell. Biol. (2003) [Pubmed]
  32. Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). Warrell, R.P., Frankel, S.R., Miller, W.H., Scheinberg, D.A., Itri, L.M., Hittelman, W.N., Vyas, R., Andreeff, M., Tafuri, A., Jakubowski, A. N. Engl. J. Med. (1991) [Pubmed]
  33. Inhibition and reversal by beta-retinoic acid of hyperplasia induced in cultured mouse prostate tissue by 3-methylcholanthrene or N-methyl-N'-nitro-N-nitrosoguanidine. Chopra, D.P., Wilkoff, L.J. J. Natl. Cancer Inst. (1976) [Pubmed]
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