Disease relevance of Lichen Planus, Oral

• Therefore, we studied, using in situ hybridization, immunohistochemistry and zymography the expression and distribution of MMP-1 and -2, and their tissue inhibitors (TIMPs -1, -2 and -3) in oral squamous cell carcinomas (SCC) and lymph node metastases as well as in oral lichen planus, epithelial dysplasias and normal buccal mucosa [1].
• Successful topical treatment of oral lichen planus and leukoplakias with fenretinide (4-HPR) [2].
• Immunomodulation by levamisole in patients with recurrent aphthous ulcers or oral lichen planus [3].
• There have been multiple case reports of squamous cell carcinoma (SCC) developing within lesions of hypertrophic cutaneous lichen planus and erosive oral lichen planus [4].
• Contact dermatitis due to eugenol used to treat oral lichen planus [5].

High impact information on Lichen Planus, Oral

• Effect of topical cyclosporine rinse on oral lichen planus [6].
• Lack of effect of cyclosporin mouthwash in oral lichen planus [7].
• To understand its pathophysiology further, the present study examined the in situ expression of chemokines and chemokine receptors in oral lichen planus [8].
• Our data suggest that the chemokines signaling via CCR5 and CXCR3, which are known to be selectively expressed by type 1 T cells, are predominantly involved in T-cell infiltration of oral lichen planus [8].
• Most lymphocytes in the lamina propria of oral lichen planus (OLP) lesions express and secrete interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha), whereas they do not secret interleukin-4 and -10 or transforming growth factor-beta [9].

Chemical compound and disease context of Lichen Planus, Oral

• Tumor necrosis factor-alpha and interferon-gamma polymorphisms contribute to susceptibility to oral lichen planus [9].
• Etretinate thus provided effective symptomatic relief for severe oral lichen planus, but side-effects were common, and six patients stopped treatment because of them [10].
• Topical tretinoin therapy and oral lichen planus [11].
• Isotretinoin for oral lichen planus [12].
• Ciclosporin vs. clobetasol in the topical management of atrophic and erosive oral lichen planus: a double-blind, randomized controlled trial [13].

Biological context of Lichen Planus, Oral

• The aim of this study was to examine keratinocyte apoptosis and caspase-3 (CPP32) expression in oral lichen planus (OLP) [14].
• Apoptosis of oral epithelial cells in oral lichen planus caused by upregulation of BMP-4 [15].
• The expression of HSP70 was significantly higher in oral leucoplakia than in oral lichen planus, possibly because of differences in cellular activity or cell proliferation [16].

Anatomical context of Lichen Planus, Oral

• Expression of MHC class II antigens (HLA DR, DP and DQ) by keratinocytes in oral lichen planus [17].
• Lymphocytes were extracted from 11 biopsy specimens of oral lichen planus (OLP) by collagenase digestion, and cell lines were expanded with repetitive cycles of stimulation (with phytohaemagglutinin) and rest in media supplemented with interleukin 2 [18].
• VCAM-1 and ICAM-1 are expressed by Langerhans cells, macrophages and endothelial cells in oral lichen planus [19].
• Epithelial cell proliferation of oral lichen planus in patients treated with an aromatic retinoid [20].
• The numbers of CD1, HLADR, HLADP and HLADQ positive, intraepithelial, dendritic cells were compared in lesions of oral lichen planus and normal oral mucosa using an immunoalkaline phosphatase technique [21].

Gene context of Lichen Planus, Oral

• Distribution of interleukin-2, -4, -10, tumour necrosis factor-alpha and transforming growth factor-beta mRNAs in oral lichen planus [22].
• OBJECTIVE: The aim of the study was to examine the expressions of p53 and proliferating cell nuclear antigen (PCNA) in oral lichen planus (OLP) in relation to its clinical behavior and the patients' oral habits [23].
• The frequencies of human leukocyte antigens--HLA-A, HLA-B, HLA-C, HLA-DR, and HLA-DQ1--were determined in a group of 40 white British patients with oral lichen planus and compared with those of healthy controls [24].
• A comparison of the pro-inflammatory, NF-kappaB-dependent cytokines: TNF-alpha, IL-1-alpha, IL-6, and IL-8 in different oral fluids from oral lichen planus patients [25].
• Serum interleukin-8 level is a more sensitive marker than serum interleukin-6 level in monitoring the disease activity of oral lichen planus [26].

Analytical, diagnostic and therapeutic context of Lichen Planus, Oral

• Methylene blue-mediated photodynamic therapy: a possible alternative treatment for oral lichen planus [27].
• In a double-blind study, 20 patients with oral lichen planus were treated twice daily with 0.1% isotretinoin gel or the vehicle alone for two months [28].
• OBJECTIVES: To determine contact allergies in patients with oral lichen planus and to monitor the effect of partial or complete replacement of amalgam fillings following a positive patch test reaction to ammoniated mercury, metallic mercury, or amalgam [29].
• Proinflammatory cytokine levels in saliva before and after treatment of (erosive) oral lichen planus with dexamethasone [30].
• Twenty-five patients with oral lichen planus confirmed by histologic examination were divided into three groups: 10 patients received topical treatment with tretinoin, 10 received systemic treatment with etretinate, and the five remaining patients, who received no treatment, served as a control group [31].

References