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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Fanconi's anaemia associated with haemophilia A.

Fanconi's anaemia and haemophilia A are born inherited diseases creating haemostatic defects. The association of these two rare diseases in one patient is described. The patient's haemophilia was studied with a newly developed immunological technique determining the plasma antigen associated with Factor VIII activity, and was found to be a genetic variant of moderately severe haemophilia A. It was not possible to demonstrate a common bone marrow defect or a common immunological or genetical background of the two diseases. The double haemostatic defect created, i.e. Factor VIII deficiency and thrombocytopenia, resulted in only a slight increase in bleeding tendency. A favourable result was obtained with corticosteroid and androgenic treatment.[1]


  1. Fanconi's anaemia associated with haemophilia A. Ljung, R., Holmberg, L., Nilsson, K.O., Thilén, A. Clin. Genet. (1979) [Pubmed]
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