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Chemical Compound Review

Blockade     2,4-dinitro-N',N'-dipropyl- 6...

Synonyms: Marathon, Endurance, Kusablock, Factor, Prodiamine, ...
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Disease relevance of Kusablock


Psychiatry related information on Kusablock


High impact information on Kusablock

  • The Highly Conserved LepA Is a Ribosomal Elongation Factor that Back-Translocates the Ribosome [11].
  • The dimeric ring-shaped sliding clamp of E. coli DNA polymerase III (beta subunit, homolog of eukaryotic PCNA) is loaded onto DNA by the clamp loader gamma complex (homolog of eukaryotic Replication Factor C, RFC) [12].
  • Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group [13].
  • BACKGROUND: Factor XI, a component of the intrinsic pathway of coagulation, contributes to the generation of thrombin, which is involved in both the formation of fibrin and protection against fibrinolysis [14].
  • CONCLUSIONS: Blockade of aldosterone receptors by spironolactone, in addition to standard therapy, substantially reduces the risk of both morbidity and death among patients with severe heart failure [15].

Chemical compound and disease context of Kusablock


Biological context of Kusablock

  • The role of HU, Factor II, and the enhancer in facilitating site-specific recombination is discussed [2].
  • Binding of CIG to fibrinogen or fibrin substrata in the presence of Factor XIII (factor) under covalent crosslinking conditions resulted in a marked increased in the ability of the substrata to support cell adhesion [21].
  • The human complement protein Factor B is encoded by a single gene in the major histocompatibility complex and is closely linked to the gene encoding the second component of complement C2 [22].
  • DNA sequencing, S1 mapping, and primer extension experiments have established that the transcription initiation site of the Factor B gene lies only 421 bp from the poly(A) site of the C2 gene [22].
  • It includes two binding sites for a host protein called Factor II or Fis (refs 4 and 5) [23].

Anatomical context of Kusablock

  • We have previously shown that a single portal vein infusion of a recombinant adeno-associated viral vector (rAAV) expressing canine Factor IX (F.IX) resulted in long-term expression of therapeutic levels of F.IX in dogs with severe hemophilia B [24].
  • Transforming Growth Factor-beta Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms [25].
  • Thus, endocytosis of Factor Xa bound to its specific endothelial cell sites may be an important factor in the balance of vessel wall hemostatic mechanisms [26].
  • In the present study we demonstrate that human monocytes can be induced by the model stimulus, lipopolysaccharide (LPS), to produce and assemble on their surface functional Factor VII/VIIa [27].
  • Since C3b deposition occurred almost exclusively on the complement-sensitive cells in the PNH erythrocyte population, these cells could be examined for the Factor H-like regulatory activities without prior isolation [28].

Associations of Kusablock with other chemical compounds


Gene context of Kusablock

  • A lod score of 16 between HLA-B and Factor B allotypes was calculated at a maximum likelihood value of the recombinant fraction of 0.04 [34].
  • CONCLUSIONS: Blockade of CCK-A receptors converts CCK-8 into a potent acid secretagogue and augments postprandial gastrin secretion [35].
  • Scatter Factor, also known as Hepatocyte Growth Factor (SF/HGF), has pleiotropic functions including direct control of cell-cell and cell-substrate adhesion in epithelia [36].
  • Here we report the isolation of an Arabidopsis thaliana cDNA that encodes a C-repeat/DRE binding factor, CBF1 (C-repeat/DRE Binding Factor 1) [37].
  • Twelve transcriptional units have now been located in a 160 kb segment of DNA that includes the genes encoding members of the serum complement system C2, Factor B (Bf) and C4 within the class III region of the human major histocompatibility complex (MHC) [38].

Analytical, diagnostic and therapeutic context of Kusablock


  1. Human recombinant DNA-derived antihemophilic factor (factor VIII) in the treatment of hemophilia A. recombinant Factor VIII Study Group. Schwartz, R.S., Abildgaard, C.F., Aledort, L.M., Arkin, S., Bloom, A.L., Brackmann, H.H., Brettler, D.B., Fukui, H., Hilgartner, M.W., Inwood, M.J. N. Engl. J. Med. (1990) [Pubmed]
  2. Host protein requirements for in vitro site-specific DNA inversion. Johnson, R.C., Bruist, M.F., Simon, M.I. Cell (1986) [Pubmed]
  3. Leisure-time physical activity levels and risk of coronary heart disease and death. The Multiple Risk Factor Intervention Trial. Leon, A.S., Connett, J., Jacobs, D.R., Rauramaa, R. JAMA (1987) [Pubmed]
  4. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. Lakka, H.M., Laaksonen, D.E., Lakka, T.A., Niskanen, L.K., Kumpusalo, E., Tuomilehto, J., Salonen, J.T. JAMA (2002) [Pubmed]
  5. Letter: Marathon running after myocardial infarction. Bassler, T.J., Scaff, J.H. JAMA (1975) [Pubmed]
  6. Trends in alcohol consumption by pregnant women. 1985 through 1988. Serdula, M., Williamson, D.F., Kendrick, J.S., Anda, R.F., Byers, T. JAMA (1991) [Pubmed]
  7. Weight control practices of U.S. adolescents and adults. Serdula, M.K., Collins, M.E., Williamson, D.F., Anda, R.F., Pamuk, E., Byers, T.E. Ann. Intern. Med. (1993) [Pubmed]
  8. Disrupted pattern of D2 dopamine receptors in the temporal lobe in schizophrenia. A postmortem study. Goldsmith, S.K., Shapiro, R.M., Joyce, J.N. Arch. Gen. Psychiatry (1997) [Pubmed]
  9. Proteolytic alterations of factor Va bound to platelets. Tracy, P.B., Nesheim, M.E., Mann, K.G. J. Biol. Chem. (1983) [Pubmed]
  10. Risk factors for the onset of eating disorders in adolescent girls: results of the McKnight longitudinal risk factor study. The McKnight Investigators, n.u.l.l. The American journal of psychiatry. (2003) [Pubmed]
  11. The Highly Conserved LepA Is a Ribosomal Elongation Factor that Back-Translocates the Ribosome. Qin, Y., Polacek, N., Vesper, O., Staub, E., Einfeldt, E., Wilson, D.N., Nierhaus, K.H. Cell (2006) [Pubmed]
  12. Mechanism of processivity clamp opening by the delta subunit wrench of the clamp loader complex of E. coli DNA polymerase III. Jeruzalmi, D., Yurieva, O., Zhao, Y., Young, M., Stewart, J., Hingorani, M., O'Donnell, M., Kuriyan, J. Cell (2001) [Pubmed]
  13. Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. Lipsky, P.E., van der Heijde, D.M., St Clair, E.W., Furst, D.E., Breedveld, F.C., Kalden, J.R., Smolen, J.S., Weisman, M., Emery, P., Feldmann, M., Harriman, G.R., Maini, R.N. N. Engl. J. Med. (2000) [Pubmed]
  14. High levels of coagulation factor XI as a risk factor for venous thrombosis. Meijers, J.C., Tekelenburg, W.L., Bouma, B.N., Bertina, R.M., Rosendaal, F.R. N. Engl. J. Med. (2000) [Pubmed]
  15. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. Pitt, B., Zannad, F., Remme, W.J., Cody, R., Castaigne, A., Perez, A., Palensky, J., Wittes, J. N. Engl. J. Med. (1999) [Pubmed]
  16. Plasma levels of C1- inhibitor complexes and cleaved C1- inhibitor in patients with hereditary angioneurotic edema. Cugno, M., Nuijens, J., Hack, E., Eerenberg, A., Frangi, D., Agostoni, A., Cicardi, M. J. Clin. Invest. (1990) [Pubmed]
  17. The contact system contributes to hypotension but not disseminated intravascular coagulation in lethal bacteremia. In vivo use of a monoclonal anti-factor XII antibody to block contact activation in baboons. Pixley, R.A., De La Cadena, R., Page, J.D., Kaufman, N., Wyshock, E.G., Chang, A., Taylor, F.B., Colman, R.W. J. Clin. Invest. (1993) [Pubmed]
  18. The effects of epinephrine infusion in patients with von Willebrand's disease. Rickles, F.R., Hoyer, L.W., Rick, M.E., Ahr, D.J. J. Clin. Invest. (1976) [Pubmed]
  19. Neurite outgrowth from embryonic chicken spinal neurons is promoted by media conditioned by muscle cells. Henderson, C.E., Huchet, M., Changeux, J.P. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  20. Progesterone Receptors Upregulate Wnt-1 To Induce Epidermal Growth Factor Receptor Transactivation and c-Src-Dependent Sustained Activation of Erk1/2 Mitogen-Activated Protein Kinase in Breast Cancer Cells. Faivre, E.J., Lange, C.A. Mol. Cell. Biol. (2007) [Pubmed]
  21. Fibroblast adhesion to fibrinogen and fibrin substrata: requirement for cold-insoluble globulin (plasma fibronectin). Grinnell, F., Feld, M., Minter, D. Cell (1980) [Pubmed]
  22. Cell-specific expression of the human complement protein factor B gene: evidence for the role of two distinct 5'-flanking elements. Wu, L.C., Morley, B.J., Campbell, R.D. Cell (1987) [Pubmed]
  23. Spatial relationship of the Fis binding sites for Hin recombinational enhancer activity. Johnson, R.C., Glasgow, A.C., Simon, M.I. Nature (1987) [Pubmed]
  24. Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response. Manno, C.S., Arruda, V.R., Pierce, G.F., Glader, B., Ragni, M., Rasko, J., Ozelo, M.C., Hoots, K., Blatt, P., Konkle, B., Dake, M., Kaye, R., Razavi, M., Zajko, A., Zehnder, J., Nakai, H., Chew, A., Leonard, D., Wright, J.F., Lessard, R.R., Sommer, J.M., Tigges, M., Sabatino, D., Luk, A., Jiang, H., Mingozzi, F., Couto, L., Ertl, H.C., High, K.A., Kay, M.A. Nat. Med. (2006) [Pubmed]
  25. Transforming Growth Factor-beta Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms. Li, M.O., Sanjabi, S., Flavell, R.A. Immunity (2006) [Pubmed]
  26. Cellular processing of bovine factors X and Xa by cultured bovine aortic endothelial cells. Nawroth, P.P., McCarthy, D., Kisiel, W., Handley, D., Stern, D.M. J. Exp. Med. (1985) [Pubmed]
  27. Monocytes can be induced by lipopolysaccharide-triggered T lymphocytes to express functional factor VII/VIIa protease activity. Tsao, B.P., Fair, D.S., Curtiss, L.K., Edgington, T.S. J. Exp. Med. (1984) [Pubmed]
  28. Paroxysmal nocturnal hemoglobinuria: deficiency in factor H-like functions of the abnormal erythrocytes. Pangburn, M.K., Schreiber, R.D., Trombold, J.S., Müller-Eberhard, H.J. J. Exp. Med. (1983) [Pubmed]
  29. Transforming Growth Factor-beta: Taking Control of T Cells' Life and Death. Horwitz, D.A. Immunity (2006) [Pubmed]
  30. Targeted inhibition of intrinsic coagulation limits cerebral injury in stroke without increasing intracerebral hemorrhage. Choudhri, T.F., Hoh, B.L., Prestigiacomo, C.J., Huang, J., Kim, L.J., Schmidt, A.M., Kisiel, W., Connolly, E.S., Pinsky, D.J. J. Exp. Med. (1999) [Pubmed]
  31. Activation of human factor IX (Christmas factor). Di Scipio, R.G., Kurachi, K., Davie, E.W. J. Clin. Invest. (1978) [Pubmed]
  32. Monoclonal anti-human factor VII antibodies. Detection in plasma of a second protein antigenically and genetically related to factor VII. Broze, G.J., Hickman, S., Miletich, J.P. J. Clin. Invest. (1985) [Pubmed]
  33. Factor VIII/von Willebrand factor protein. Galactose a cryptic determinant of von Willebrand factor activity. Gralnick, H.R. J. Clin. Invest. (1978) [Pubmed]
  34. The chromosomal order of genes controlling the major histocompatibility complex, properdin factor B, and deficiency of the second component of complement. Raum, D., Glass, D., Carpenter, C.B., Alper, C.A., Schur, P.H. J. Clin. Invest. (1976) [Pubmed]
  35. Cholecystokinin is a negative regulator of gastric acid secretion and postprandial release of gastrin in humans. Schmidt, W.E., Schenk, S., Nustede, R., Holst, J.J., Fölsch, U.R., Creutzfeldt, W. Gastroenterology (1994) [Pubmed]
  36. Targeting of the SF/HGF receptor to the basolateral domain of polarized epithelial cells. Crepaldi, T., Pollack, A.L., Prat, M., Zborek, A., Mostov, K., Comoglio, P.M. J. Cell Biol. (1994) [Pubmed]
  37. Arabidopsis thaliana CBF1 encodes an AP2 domain-containing transcriptional activator that binds to the C-repeat/DRE, a cis-acting DNA regulatory element that stimulates transcription in response to low temperature and water deficit. Stockinger, E.J., Gilmour, S.J., Thomashow, M.F. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  38. Characterisation of the novel gene G11 lying adjacent to the complement C4A gene in the human major histocompatibility complex. Sargent, C.A., Anderson, M.J., Hsieh, S.L., Kendall, E., Gomez-Escobar, N., Campbell, R.D. Hum. Mol. Genet. (1994) [Pubmed]
  39. Treatment of the bleeding tendency in uremia with cryoprecipitate. Janson, P.A., Jubelirer, S.J., Weinstein, M.J., Deykin, D. N. Engl. J. Med. (1980) [Pubmed]
  40. Binge drinking among US adults. Naimi, T.S., Brewer, R.D., Mokdad, A., Denny, C., Serdula, M.K., Marks, J.S. JAMA (2003) [Pubmed]
  41. The spread of the obesity epidemic in the United States, 1991-1998. Mokdad, A.H., Serdula, M.K., Dietz, W.H., Bowman, B.A., Marks, J.S., Koplan, J.P. JAMA (1999) [Pubmed]
  42. Failure to use seat belts in the United States. The 1981-1983 Behavioral Risk Factor Surveys. Goldbaum, G.M., Remington, P.L., Powell, K.E., Hogelin, G.C., Gentry, E.M. JAMA (1986) [Pubmed]
  43. Isolation and study of an acquired inhibitor of human coagulation factor V. Nesheim, M.E., Nichols, W.L., Cole, T.L., Houston, J.G., Schenk, R.B., Mann, K.G., Bowie, E.J. J. Clin. Invest. (1986) [Pubmed]
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