Demonstration of Y/autosomal translocations using distamycin A.
The condensation of the brightly fluorescing Y-heterochromatin is prevented by cultivating leukocytes in a medium containing distamycin A. This technique provides a reliable method for the identification of those Y/autosomal translocations in which Y heterochromatin is involved. A case of a familiar Y/22 translocation and the distamycin A technique are described.[1]References
- Demonstration of Y/autosomal translocations using distamycin A. Schmid, M. Hum. Genet. (1979) [Pubmed]
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