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Elias, E. et al.

Chlorpromazine and its metabolites alter polymerization and gelation of actin.

Hepatic hydroxylated metabolites of chlorpromazine (10(-5)M to 10(-4)M), a frequently used phenothiazine tranquilizer, produce solid gel formation with filamentous actin, but the less toxic chlorpromazine sulfoxide metabolite does not. At higher concentrations (5 x 10(-4)M) chlorpromazine inhibits actin polymerization. These dose-response relationships parallel the drug's hepatic toxicity in vivo and suggest that interactions between chloropromazine or chlorpromazine metabolites and actin could be an underlying mechanism of cell injury.[1]

References

Chlorpromazine and its metabolites alter polymerization and gelation of actin. Elias, E., Boyer, J.L. Science (1979) [Pubmed]

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