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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A single rat fibronectin gene generates three different mRNAs by alternative splicing of a complex exon.

Three fibronectin mRNAs exist in rat liver, differing by the presence or absence of segments of 285 or 360 bases at a point within the coding region. We previously proposed that the three mRNAs are encoded by a single gene and arise via alternative splicing of a common transcript. In order to test this hypothesis, we have isolated clones spanning approximately half of the fibronectin gene from a Fisher rat genomic library; blot hybridization analyses reveal the presence of only one fibronectin gene in the haploid rat genome. We determined the sequence of a portion (1221 nucleotides) of this gene. This sequence shows clearly that the three fibronectin mRNAs encoded by this gene are generated by a pattern of alternative splicing in which one 5' splice site can be paired with any one of three 3' splice sites, one at the beginning of, and two within, a single complex exon.[1]

References

  1. A single rat fibronectin gene generates three different mRNAs by alternative splicing of a complex exon. Tamkun, J.W., Schwarzbauer, J.E., Hynes, R.O. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
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