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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Blockade of chlorpropamide alcohol flush by aspirin.

The blocking effects of aspirin, chlorpheniramine, and cimetidine were tested against the flush provoked by alcohol in twenty-four chlorpropamide-treated patients with non-insulin-dependent diabetes mellitus. Active preparations were compared in a double-blind manner with an indistinguishable placebo. Aspirin significantly decreased the number of patients who flushed. Five patients studied in detail all showed suppression of chlorpropamide/alcohol flush by aspirin, with a mean facial temperature increase during the flush of 2.4 degrees C after pretreatment with placebo and an increase of 0.4 degrees C after pretreatment with aspirin.[1]

References

  1. Blockade of chlorpropamide alcohol flush by aspirin. Strakosch, C.R., Jefferys, D.B., Keen, H. Lancet (1980) [Pubmed]
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