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MeSH Review

Diabetes Mellitus, Type 2

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Disease relevance of Diabetes Mellitus, Type 2


Psychiatry related information on Diabetes Mellitus, Type 2


High impact information on Diabetes Mellitus, Type 2


Chemical compound and disease context of Diabetes Mellitus, Type 2


Biological context of Diabetes Mellitus, Type 2


Anatomical context of Diabetes Mellitus, Type 2


Gene context of Diabetes Mellitus, Type 2

  • Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles [31].
  • In contrast to the glucokinase and HNF-1alpha genes, mutations in the HNF-4alpha gene are a relatively uncommon cause of MODY, and our understanding of the MODY1 form of diabetes is based on studies of only a single family, the R-W pedigree [32].
  • Recent studies have identified multiple sequence variants of IRS-1, especially in patients with non-insulin-dependent diabetes mellitus [33].
  • We have examined 10 unrelated Caucasian families in which MODY/NIDDM co-segregated with markers for MODY3 for mutations in the HNF-1alpha gene (TCF1) [34].
  • These studies strongly suggest that heterozygous mutations in the HNF-1beta gene are associated with a syndrome characterized by MODY and severe, non-diabetic renal disease [35].

Analytical, diagnostic and therapeutic context of Diabetes Mellitus, Type 2


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  15. Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes. Cline, G.W., Petersen, K.F., Krssak, M., Shen, J., Hundal, R.S., Trajanoski, Z., Inzucchi, S., Dresner, A., Rothman, D.L., Shulman, G.I. N. Engl. J. Med. (1999) [Pubmed]
  16. Efficacy of metformin in non-insulin-dependent diabetes mellitus. Gueriguian, J., Green, L., Misbin, R.I., Stadel, B., Fleming, G.A. N. Engl. J. Med. (1996) [Pubmed]
  17. Effect of troglitazone in type 2 diabetes mellitus. Gorson, D.M. N. Engl. J. Med. (1998) [Pubmed]
  18. Lovastatin for lowering cholesterol levels in non-insulin-dependent diabetes mellitus. Garg, A., Grundy, S.M. N. Engl. J. Med. (1988) [Pubmed]
  19. Development and progression of renal disease in Pima Indians with non-insulin-dependent diabetes mellitus. Diabetic Renal Disease Study Group. Nelson, R.G., Bennett, P.H., Beck, G.J., Tan, M., Knowler, W.C., Mitch, W.E., Hirschman, G.H., Myers, B.D. N. Engl. J. Med. (1996) [Pubmed]
  20. Missense glucokinase mutation in maturity-onset diabetes of the young and mutation screening in late-onset diabetes. Stoffel, M., Patel, P., Lo, Y.M., Hattersley, A.T., Lucassen, A.M., Page, R., Bell, J.I., Bell, G.I., Turner, R.C., Wainscoat, J.S. Nat. Genet. (1992) [Pubmed]
  21. Increased insulin concentrations in nondiabetic offspring of diabetic parents. Haffner, S.M., Stern, M.P., Hazuda, H.P., Mitchell, B.D., Patterson, J.K. N. Engl. J. Med. (1988) [Pubmed]
  22. Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. Stumvoll, M., Nurjhan, N., Perriello, G., Dailey, G., Gerich, J.E. N. Engl. J. Med. (1995) [Pubmed]
  23. A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q. Vaxillaire, M., Boccio, V., Philippi, A., Vigouroux, C., Terwilliger, J., Passa, P., Beckmann, J.S., Velho, G., Lathrop, G.M., Froguel, P. Nat. Genet. (1995) [Pubmed]
  24. Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene. Walston, J., Silver, K., Bogardus, C., Knowler, W.C., Celi, F.S., Austin, S., Manning, B., Strosberg, A.D., Stern, M.P., Raben, N. N. Engl. J. Med. (1995) [Pubmed]
  25. Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Galli, J., Li, L.S., Glaser, A., Ostenson, C.G., Jiao, H., Fakhrai-Rad, H., Jacob, H.J., Lander, E.S., Luthman, H. Nat. Genet. (1996) [Pubmed]
  26. Association between polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus. Groop, L.C., Kankuri, M., Schalin-Jäntti, C., Ekstrand, A., Nikula-Ijäs, P., Widén, E., Kuismanen, E., Eriksson, J., Franssila-Kallunki, A., Saloranta, C. N. Engl. J. Med. (1993) [Pubmed]
  27. Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus. Maddux, B.A., Sbraccia, P., Kumakura, S., Sasson, S., Youngren, J., Fisher, A., Spencer, S., Grupe, A., Henzel, W., Stewart, T.A. Nature (1995) [Pubmed]
  28. Pathophysiology and pharmacological treatment of insulin resistance. Matthaei, S., Stumvoll, M., Kellerer, M., Häring, H.U. Endocr. Rev. (2000) [Pubmed]
  29. Long-term effect of insulin on glucose transport and insulin binding in cultured adipocytes from normal and obese humans with and without non-insulin-dependent diabetes. Sinha, M.K., Taylor, L.G., Pories, W.J., Flickinger, E.G., Meelheim, D., Atkinson, S., Sehgal, N.S., Caro, J.F. J. Clin. Invest. (1987) [Pubmed]
  30. Rat amylin: cloning and tissue-specific expression in pancreatic islets. Leffert, J.D., Newgard, C.B., Okamoto, H., Milburn, J.L., Luskey, K.L. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  31. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Brüning, J.C., Winnay, J., Bonner-Weir, S., Taylor, S.I., Accili, D., Kahn, C.R. Cell (1997) [Pubmed]
  32. Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor-4alpha/MODY1 gene. Lindner, T., Gragnoli, C., Furuta, H., Cockburn, B.N., Petzold, C., Rietzsch, H., Weiss, U., Schulze, J., Bell, G.I. J. Clin. Invest. (1997) [Pubmed]
  33. A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies. Almind, K., Inoue, G., Pedersen, O., Kahn, C.R. J. Clin. Invest. (1996) [Pubmed]
  34. Identification of nine novel mutations in the hepatocyte nuclear factor 1 alpha gene associated with maturity-onset diabetes of the young (MODY3). Vaxillaire, M., Rouard, M., Yamagata, K., Oda, N., Kaisaki, P.J., Boriraj, V.V., Chevre, J.C., Boccio, V., Cox, R.D., Lathrop, G.M., Dussoix, P., Philippe, J., Timsit, J., Charpentier, G., Velho, G., Bell, G.I., Froguel, P. Hum. Mol. Genet. (1997) [Pubmed]
  35. A novel syndrome of diabetes mellitus, renal dysfunction and genital malformation associated with a partial deletion of the pseudo-POU domain of hepatocyte nuclear factor-1beta. Lindner, T.H., Njolstad, P.R., Horikawa, Y., Bostad, L., Bell, G.I., Sovik, O. Hum. Mol. Genet. (1999) [Pubmed]
  36. Effects of tolazamide and exogenous insulin on insulin action in patients with non-insulin-dependent diabetes mellitus. Firth, R.G., Bell, P.M., Rizza, R.A. N. Engl. J. Med. (1986) [Pubmed]
  37. Influence of treatment with diet alone on oral glucose-tolerance test and plasma sugar and insulin levels in patients with maturity-onset diabetes mellitus. Doar, J.W., Wilde, C.E., Thompson, M.E., Sewell, P.F. Lancet (1975) [Pubmed]
  38. Glyburide or insulin for metabolic control in non-insulin-dependent diabetes mellitus. A randomized, double-blind study. Nathan, D.M., Roussell, A., Godine, J.E. Ann. Intern. Med. (1988) [Pubmed]
  39. Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion. Efrat, S., Leiser, M., Wu, Y.J., Fusco-DeMane, D., Emran, O.A., Surana, M., Jetton, T.L., Magnuson, M.A., Weir, G., Fleischer, N. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  40. The enteric enhancement of glucose-stimulated insulin release. The role of GIP in aging, obesity, and non-insulin-dependent diabetes mellitus. Elahi, D., Andersen, D.K., Muller, D.C., Tobin, J.D., Brown, J.C., Andres, R. Diabetes (1984) [Pubmed]
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