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Chemical Compound Review

Diabinese     1-(4-chlorophenyl)sulfonyl-3- propyl-urea

Synonyms: Glucamide, Insogen, Meldian, Clorpropamid, chlorpropamide, ...
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Disease relevance of chlorpropamide


Psychiatry related information on chlorpropamide


High impact information on chlorpropamide


Chemical compound and disease context of chlorpropamide


Biological context of chlorpropamide


Anatomical context of chlorpropamide


Associations of chlorpropamide with other chemical compounds


Gene context of chlorpropamide


Analytical, diagnostic and therapeutic context of chlorpropamide


  1. Chlorpropamide-induced hypoglycemia. A dramatic presentation of celiac disease. Rosenbaum, L.H., Rosenbaum, H. JAMA (1982) [Pubmed]
  2. Chlorpropamide-induced granulomas. A probable hypersensitivity reaction in liver and bone marrow. Rigberg, L.A., Robinson, M.J., Espiritu, C.R. JAMA (1976) [Pubmed]
  3. Chlorpropamide-induced agranulocytosis. Tucker, S.C., Lynch, J.P., Ansell, B.F. JAMA (1977) [Pubmed]
  4. Distinguishing features of idiopathic flushing and carcinoid syndrome. Aldrich, L.B., Moattari, A.R., Vinik, A.I. Arch. Intern. Med. (1988) [Pubmed]
  5. Rates of hypoglycemia in users of sulfonylureas. van Staa, T., Abenhaim, L., Monette, J. Journal of clinical epidemiology. (1997) [Pubmed]
  6. Chlorpropamide action on renal concentrating mechanism in rats with hypothalamic diabetes insipidus. Kusano, E., Braun-Werness, J.L., Vick, D.J., Keller, M.J., Dousa, T.P. J. Clin. Invest. (1983) [Pubmed]
  7. A case of chronic liver disease due to tolazamide. Nakao, N.L., Gelb, A.M., Stenger, R.J., Siegel, J.H. Gastroenterology (1985) [Pubmed]
  8. Facial skin temperature and the chlorpropamide/alcohol flush in diabetics. Radder, J.K., Box, M.C., Lemkes, H.H. Lancet (1980) [Pubmed]
  9. Blockade of chlorpropamide alcohol flush by aspirin. Strakosch, C.R., Jefferys, D.B., Keen, H. Lancet (1980) [Pubmed]
  10. Chlorpropamide alcohol flushing and diabetic retinopathy. Leslie, R.D., Barnett, A.H., Pyke, D.A. Lancet (1979) [Pubmed]
  11. Once-daily use of glyburide. Ginier, P., Madan, S., Fajardo, F., Levin, S.R. Am. J. Med. (1985) [Pubmed]
  12. Clinical resistance to vasopressin. Detection of antibody by hemagglutination. Soler, N.G., Myers, W.L., Sode, J., Wortsman, J. Arch. Intern. Med. (1979) [Pubmed]
  13. The effects of chlorpropamide and insulin on serum lipids, lipoproteins and fractional triglyceride removal. Paisey, R., Elkeles, R.S., Hambley, J., Magill, P. Diabetologia (1978) [Pubmed]
  14. Water metabolism in diabetes mellitus. Davis, F.B., Davis, P.J. Am. J. Med. (1981) [Pubmed]
  15. Improved control of non-insulin-dependent diabetes mellitus by combined halofenate and chlorpropamide therapy. Kohl, E.A., Magner, J.A., Persellin, S.T., Vaughan, G.M., Kudzma, D.J., Friedberg, S.J. Diabetes Care (1984) [Pubmed]
  16. Chlorpropamide raises fructose-2,6-bisphosphate concentration and inhibits gluconeogenesis in isolated rat hepatocytes. Monge, L., Mojena, M., Ortega, J.L., Samper, B., Cabello, M.A., Feliu, J.E. Diabetes (1986) [Pubmed]
  17. Association of aldehyde dehydrogenase with inheritance of NIDDM. Suzuki, Y., Muramatsu, T., Taniyama, M., Atsumi, Y., Kawaguchi, R., Higuchi, S., Hosokawa, K., Asahina, T., Murata, C., Matsuoka, K. Diabetologia (1996) [Pubmed]
  18. Hormonal and metabolic effects of chlorpropamide, glibenclamide and placebo in a cross-over study in diabetics not controlled by diet alone. Sönksen, P.H., Lowy, C., Perkins, J.R., West, T.E. Diabetologia (1981) [Pubmed]
  19. Roles of chlorpropamide, alcohol and acetaldehyde in determining the chlorpropamide-alcohol flush. Groop, L., Eriksson, C.J., Huupponen, R., Ylikahri, R., Pelkonen, R. Diabetologia (1984) [Pubmed]
  20. Sulfonylureas do not affect insulin binding or glycemic control in insulin-dependent diabetics. Grunberger, G., Ryan, J., Gorden, P. Diabetes (1982) [Pubmed]
  21. Hepatic effects of chlorpropamide: inhibition of glucagon-stimulated gluconeogenesis in perfused livers of fasted rats. Blumenthal, S.A., Whitmer, K.R. Diabetes (1979) [Pubmed]
  22. Association of hyperinsulinemia with chlorpropamide toxicity. Klonoff, D.C. Am. J. Med. (1988) [Pubmed]
  23. The significance of the cerebrospinal fluid examination in the management of chlorpropamide-induced hypoglycemia. Kaplinsky, N., Frankl, O. Diabetes Care (1980) [Pubmed]
  24. Increase of plasma acetaldehyde. An objective indicator of the chlorpropamide alcohol flush. Jerntorp, P., Ohlin, H., Bergström, B., Almér, L.O. Diabetes (1981) [Pubmed]
  25. Sulphonylureas in vitro do not alter insulin binding or insulin effect on amino acid transport in rat hepatocytes. Dolais-Kitabgi, J., Alengrin, F., Freychet, P. Diabetologia (1983) [Pubmed]
  26. Efficacy of indapamide in central diabetes insipidus. Tetiker, T., Sert, M., Koçak, M. Arch. Intern. Med. (1999) [Pubmed]
  27. Chlorpropamide 2-hydroxylation is catalysed by CYP2C9 and CYP2C19 in vitro: chlorpropamide disposition is influenced by CYP2C9, but not by CYP2C19 genetic polymorphism. Shon, J.H., Yoon, Y.R., Kim, M.J., Kim, K.A., Lim, Y.C., Liu, K.H., Shin, D.H., Lee, C.H., Cha, I.J., Shin, J.G. British journal of clinical pharmacology. (2005) [Pubmed]
  28. Effect of chlorpropamide on renal response to parathyroid hormone in normal subjects and in patients with hypoparathyroidism and pseudohypoparathyroidism. Coulson, R., Moses, A.M. J. Pharmacol. Exp. Ther. (1975) [Pubmed]
  29. Water retention after oral chlorpropamide is associated with an increase in renal papillary arginine vasopressin receptors. Hensen, J., Haenelt, M., Gross, P. Eur. J. Endocrinol. (1995) [Pubmed]
  30. Reversible mild diabetes in children after treatment with chlorpropamide. Mutch, W.J., Stowers, J.M. Lancet (1980) [Pubmed]
  31. Potentiation of the hepatic action of insulin by chlorpropamide. Blumenthal, S.A. Diabetes (1977) [Pubmed]
  32. Islet changes induced by hyperglycemia in rats. Effect of insulin or chlorpropamide therapy. Clark, A., Bown, E., King, T., Vanhegan, R.I., Turner, R.C. Diabetes (1982) [Pubmed]
  33. Medication compliance in non-insulin-dependent diabetes: a randomized comparison of chlorpropamide and insulin. Diehl, A.K., Sugarek, N.J., Bauer, R.L. Diabetes Care (1985) [Pubmed]
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