The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Regioselectivity and reactivity in microsomal hydroxylation of a series of N-acyl- and N-sulfonylamines in rats.

Regioselectivity and overall reactivity in the hydroxylation of a series of substituted N-benzoyl- and benzenesulfonyl aliphatic and alicyclic amines with rat liver microsomes were investigated. The hydroxylation occurred predominantly at the position gamma to the nitrogen atom. para-Alkyl-substituted benzoylamines were hydroxylated at both the benzylic positions as well as the gamma-position, whereas para-substituted benzenesulfonylamines were hydroxylated mainly at the benzylic position. The relative overall reactivity of primary, secondary, and tertiary carbon atoms was about 1:3:8, and the contribution of substituents adjoining to the reaction site was negligible. Benzylic hydroxylation proceeded stereoselectively, whereas gamma-hydroxylation gave optically inactive metabolites; the inter- and intramolecular isotope effects in the hydroxylation were 1.6 and 7.2, respectively.[1]

References

 
WikiGenes - Universities