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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Metabolic basis of hypertyrosinemia in liver disease.

Serum tyrosine concentrations in patients with liver cirrhosis and with advanced fatty degeneration of the liver were 143 and 140 mumol/L, respectively, as compared with 65 mumol/l in normal controls. In biopsy samples of histologically normal livers, total tyrosine aminotransferase activity was 10.5 +/- 1.8 nmol p-hydroxyphenylpyruvate formed/mg of protein per min (mean +/- SEM; n = 10) whereas the corresponding figures for 7 cirrhotics were 4.95 +/- 0.85. The enzyme activity was normal in moderate adipose degeneration of the liver, but it was reduced when more than 50% of the hepatocytes were occupied by fat. It is suggested that the hypertyrosinemia of cirrhotics is, at least in part, due to decreased tyrosine aminotransferase activity.[1]


  1. Metabolic basis of hypertyrosinemia in liver disease. Andersson, S.M., Salaspuro, M., Ohisalo, J.J. Gastroenterology (1982) [Pubmed]
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