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Chemical Compound Review

Testacid     3-(4-hydroxyphenyl)-2-oxo- propanoic acid

Synonyms: Testacide, SureCN24157, CHEMBL607712, AG-C-41656, AG-E-05222, ...
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Disease relevance of p-Hydroxyphenylpyruvic acid


High impact information on p-Hydroxyphenylpyruvic acid


Chemical compound and disease context of p-Hydroxyphenylpyruvic acid


Biological context of p-Hydroxyphenylpyruvic acid


Anatomical context of p-Hydroxyphenylpyruvic acid


Associations of p-Hydroxyphenylpyruvic acid with other chemical compounds


Gene context of p-Hydroxyphenylpyruvic acid


  1. Blue color, metal content, and substrate binding in 4-hydroxyphenylpyruvate dioxygenase from Pseudomonas sp. strain P. J. 874. Lindstedt, S., Rundgren, M. J. Biol. Chem. (1982) [Pubmed]
  2. Subcellular localization and purification of a p-hydroxyphenylpyruvate dioxygenase from cultured carrot cells and characterization of the corresponding cDNA. Garcia, I., Rodgers, M., Lenne, C., Rolland, A., Sailland, A., Matringe, M. Biochem. J. (1997) [Pubmed]
  3. Metabolic studies of transient tyrosinemia in premature infants. Fernbach, S.A., Summons, R.E., Pereira, W.E., Duffield, A.M. Pediatr. Res. (1975) [Pubmed]
  4. A Streptomyces avermitilis gene encoding a 4-hydroxyphenylpyruvic acid dioxygenase-like protein that directs the production of homogentisic acid and an ochronotic pigment in Escherichia coli. Denoya, C.D., Skinner, D.D., Morgenstern, M.R. J. Bacteriol. (1994) [Pubmed]
  5. Tyrosinemia produced by 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione (NTBC) in experimental animals and its relationship to corneal injury. Lock, E.A., Gaskin, P., Ellis, M., Provan, W.M., Smith, L.L. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  6. Metabolic basis of hypertyrosinemia in liver disease. Andersson, S.M., Salaspuro, M., Ohisalo, J.J. Gastroenterology (1982) [Pubmed]
  7. Direct link between cytokine activity and a catalytic site for macrophage migration inhibitory factor. Swope, M., Sun, H.W., Blake, P.R., Lolis, E. EMBO J. (1998) [Pubmed]
  8. The aromatic amino acid pathway branches at L-arogenate in Euglena gracilis. Byng, G.S., Whitaker, R.J., Shapiro, C.L., Jensen, R.A. Mol. Cell. Biol. (1981) [Pubmed]
  9. Aspartate aminotransferase generates proagonists of the aryl hydrocarbon receptor. Bittinger, M.A., Nguyen, L.P., Bradfield, C.A. Mol. Pharmacol. (2003) [Pubmed]
  10. Characterization and subcellular compartmentation of recombinant 4-hydroxyphenylpyruvate dioxygenase from Arabidopsis in transgenic tobacco. Garcia, I., Rodgers, M., Pepin, R., Hsieh, T.F., Matringe, M. Plant Physiol. (1999) [Pubmed]
  11. The homogentisate pathway: a central catabolic pathway involved in the degradation of L-phenylalanine, L-tyrosine, and 3-hydroxyphenylacetate in Pseudomonas putida. Arias-Barrau, E., Olivera, E.R., Luengo, J.M., Fernández, C., Galán, B., García, J.L., Díaz, E., Miñambres, B. J. Bacteriol. (2004) [Pubmed]
  12. Representing and reasoning about protein families using generative and discriminative methods. Mian, I.S., Dubchak, I. J. Comput. Biol. (2000) [Pubmed]
  13. A novel therapeutic trial of homogentisic aciduria in a murine model of alkaptonuria. Suzuki, Y., Oda, K., Yoshikawa, Y., Maeda, Y., Suzuki, T. J. Hum. Genet. (1999) [Pubmed]
  14. Tritium isotope effects in the reaction catalyzed by 4-hydroxyphenylpyruvate dioxygenase from pseudomonas sp. strain P.J. 874. Rundgren, M. Biochim. Biophys. Acta (1982) [Pubmed]
  15. Determination of p-hydroxyphenylpyruvate, p-hydroxyphenyllactate and tyrosine in normal human plasma by gas chromatography-mass spectrometry isotope-dilution assay. Deutsch, J.C. J. Chromatogr. B Biomed. Sci. Appl. (1997) [Pubmed]
  16. Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity. Lubetsky, J.B., Swope, M., Dealwis, C., Blake, P., Lolis, E. Biochemistry (1999) [Pubmed]
  17. Engineering p-hydroxyphenylpyruvate dioxygenase to a p-hydroxymandelate synthase and evidence for the proposed benzene oxide intermediate in homogentisate formation. Gunsior, M., Ravel, J., Challis, G.L., Townsend, C.A. Biochemistry (2004) [Pubmed]
  18. Purification and characterization of a dimeric phenylalanine dehydrogenase from Rhodococcus maris K-18. Misono, H., Yonezawa, J., Nagata, S., Nagasaki, S. J. Bacteriol. (1989) [Pubmed]
  19. Characterization of transplastomic tobacco plants with a plastid localized barley 4-hydroxyphenylpyruvate dioxygenase. Falk, J., Brosch, M., Schäfer, A., Braun, S., Krupinska, K. J. Plant Physiol. (2005) [Pubmed]
  20. The Tetrahymena homolog of bacterial and mammalian 4-hydroxyphenylpyruvate dioxygenases localizes to membranes of the endoplasmic reticulum. Neve, S., Tornehave, D., Corydon, T.J., Kristiansen, K. Cell Biol. Int. (2000) [Pubmed]
  21. Tyrosine aminotransferase activity in human fetal liver. Andersson, S.M., Räihä, N.C., Ohisalo, J.J. J. Dev. Physiol. (1980) [Pubmed]
  22. Obligatory biosynthesis of L-tyrosine via the pretyrosine branchlet in coryneform bacteria. Fazel, A.M., Jensen, R.A. J. Bacteriol. (1979) [Pubmed]
  23. SC-0051, a 2-benzoyl-cyclohexane-1,3-dione bleaching herbicide, is a potent inhibitor of the enzyme p-hydroxyphenylpyruvate dioxygenase. Schulz, A., Ort, O., Beyer, P., Kleinig, H. FEBS Lett. (1993) [Pubmed]
  24. Mutations in the 4-hydroxyphenylpyruvic acid dioxygenase gene are responsible for tyrosinemia type III and hawkinsinuria. Tomoeda, K., Awata, H., Matsuura, T., Matsuda, I., Ploechl, E., Milovac, T., Boneh, A., Scott, C.R., Danks, D.M., Endo, F. Mol. Genet. Metab. (2000) [Pubmed]
  25. Synthesis and antioxidant properties of a new lipophilic ascorbic acid analogue. Cotelle, P., Cotelle, N., Teissier, E., Vezin, H. Bioorg. Med. Chem. (2003) [Pubmed]
  26. Animal models reveal pathophysiologies of tyrosinemias. Endo, F., Tanaka, Y., Tomoeda, K., Tanoue, A., Tsujimoto, G., Nakamura, K. J. Nutr. (2003) [Pubmed]
  27. The protein encoded by the Shewanella colwelliana melA gene is a p-hydroxyphenylpyruvate dioxygenase. Ruzafa, C., Solano, F., Sanchez-Amat, A. FEMS Microbiol. Lett. (1994) [Pubmed]
  28. Inhibition of transketolase by p-hydroxyphenylpyruvate. Solovjeva, O.N., Kochetov, G.A. FEBS Lett. (1999) [Pubmed]
  29. Changes in liver tyrosine aminotransferase after acute and chronic administration of morphine in the rat. Santagostino, A., Giagnoni, G., Reina, R., Spadaro, C., Ferri, S. Arch. Toxicol. Suppl. (1978) [Pubmed]
  30. On kynureninase activity. Shibata, Y., Takeuchi, F., Tsubouchi, R., Haneda, M., Ohta, T., Nakatsuka, M., Nisimoto, Y., Tamai, T., Nomura, S., Fujimoto, H. Adv. Exp. Med. Biol. (1991) [Pubmed]
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