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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Production of human monoclonal antibody to rhesus D antigen.

Peripheral-blood mononuclear cells from an individual known to produce antibody to the rhesus D blood group were enriched for specific antibody-producing cells before transformation with Epstein-Barr virus. An anti-rhesus-D antibody-producing cell line (UCH D4) was obtained and cloned. Culture supernatants contained about 20 micrograms/ml of rhesus-D-specific IgG-class antibody. The antibody reactivity compared well with that of reagents used routinely for rhesus blood-grouping.[1]


  1. Production of human monoclonal antibody to rhesus D antigen. Crawford, D.H., Barlow, M.J., Harrison, J.F., Winger, L., Huehns, E.R. Lancet (1983) [Pubmed]
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