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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Intramuscular human interferon-beta injections in treatment of condylomata acuminata.

A two-part study was done to assess the value of human fibroblast interferon (IFN-beta) in the treatment of condylomata acuminata. The first part was an open study of different IFN-beta preparations, which showed that intramuscular injection was the most suitable mode of administration of IFN-beta. In the double-blind placebo section 22 patients were given injections of 2 X 10(6) units IFN-beta or placebo for 10 consecutive days and followed up for 3 months. In 9 of the 11 in the IFN-beta group and 2 in the placebo group lesions disappeared from about 5 weeks after completion of the course of injections. After 3 months 8 of the non-responders were given a course of IFN-beta and all responded to treatment. None of those who had responded has had a recurrence, the disease-free period now being 12 months. Changes in (2'-5')oligo A synthetase levels in white blood cells confirm that intramuscular injections of IFN-beta produce a systemic response.[1]


  1. Intramuscular human interferon-beta injections in treatment of condylomata acuminata. Schonfeld, A., Nitke, S., Schattner, A., Wallach, D., Crespi, M., Hahn, T., Levavi, H., Yarden, O., Shoham, J., Doerner, T. Lancet (1984) [Pubmed]
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