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MeSH Review

Condylomata Acuminata

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Disease relevance of Condylomata Acuminata

  • In this study, we analysed 98 formalin-fixed, paraffin-embedded condylomata acuminata obtained from 54 patients for the presence of URR-duplication variants of HPV 6 [1].
  • OBJECTIVE: To assess the clinical and molecular response of patients with recurrent high-grade vulvar, vaginal, or cervical intraepithelial neoplasia treated with topical 1-2(2-methylpropyl)-1H-imidazo [4,5-c] quinolin-4-amine (imiquimod) cream 5%, an immune response modifier with known efficacy in the treatment of external genital warts [2].
  • The L1 genes of two human papillomavirus type 16 (HPV16) isolates derived from condylomata acuminata were used to express the L1 major capsid protein in insect cells via recombinant baculoviruses [3].
  • BACKGROUND AND OBJECTIVES: Though human papillomavirus (HPV) DNA can be detected in the majority of condylomata acuminata, the major capsid protein of HPV (L1 protein) can be detected in only 10% to 50% of lesions in immunohistochemical assays [4].
  • This study demonstrates the presence of specific antibodies directed at native HPV-11 viral particles in the sera of patients with condylomata acuminata, and describes a test which can be used in future serological studies of this common sexually transmitted disease [5].

Psychiatry related information on Condylomata Acuminata

  • DESIGN--The study included 101 randomly selected male partners of females with known GPVI, or with penile symptoms such as itching, burning and dyspareunia who did not exhibit overt genital warts but appeared to be afflicted with acetowhite penile lesions after topical application of 5% acqueous acetic acid [6].

High impact information on Condylomata Acuminata


Chemical compound and disease context of Condylomata Acuminata

  • Combined surgery and cidofovir is an effective treatment for genital warts in HIV-infected patients [10].
  • These observations lead to a simplified stable preparation of modest nitric acid concentration with adequate nitrate reduction products for efficacy in the topical ablation of small skin lesions such as condylomata acuminata [12].
  • Use of a preparation technique that completely consumes all the oxidizable organic components added to generate nitrite results in a stable preparation that is effective, well tolerated, and convenient in the treatment of anogenital warts (condylomata acuminata) [12].
  • Penoscopy was performed after application of acetic acid to identify flat lesions, papular lesions, condylomata acuminata and pearly penile papules (PPPs) [13].
  • Particular benefit has also been shown with use of eutectic lidocaine/prilocaine cream in association with treatment of condylomata acuminata in both men and women, and it appears to provide a useful alternative to lidocaine infiltration in this context [14].

Biological context of Condylomata Acuminata


Anatomical context of Condylomata Acuminata


Gene context of Condylomata Acuminata

  • BACKGROUND: Virus-like particles (VLPs) formed by the human papillomavirus (HPV) L1 capsid protein are currently being tested in clinical trials as prophylactic vaccines against genital warts and cervical cancer [22].
  • CONCLUSION: Regional IFN is a moderately effective and safe treatment in patients with recalcitrant anogenital condylomata acuminata [23].
  • The most striking reactivities present in sera from patients with genital warts were to the HPV-6b L1 ORF protein and, to a lesser extent, to the HPV-6b L2 ORF protein [24].
  • Condylomata acuminata in IDDM [25].
  • Here we targeted the E6/E7 mRNA of HPV11, a type implicated in causation of genital warts, using molecular reagents [26].

Analytical, diagnostic and therapeutic context of Condylomata Acuminata

  • It was concluded that laser surgery followed by topical application of 0.5% idoxuridine cream for two to four weeks seems to be highly effective in the treatment of longstanding, therapy-resistant genital warts in men [27].
  • External genital warts were treated with either trichloracetic acid or cryotherapy (using liquid nitrogen) on a once weekly basis [28].
  • Antibodies to human papillomavirus type 11 virus-like particles in sera of patients with genital warts and in control groups [29].
  • We previously established, using an ELISA, the presence of specific antibodies directed at human papillomavirus (HPV) type 11 virions in the sera of patients with condylomata acuminata, mostly a disease of young adults that, like recurrent respiratory papillomatosis (RRP), is caused by two closely related HPVs, types 6 and 11 [30].
  • Colposcopy, which is the examination of the female genital tract that generally is performed after the application of acetic acid, has been an effective tool in the diagnosis of genital warts (condyloma acuminatum) in women for years [31].


  1. Demonstration of URR-duplication variants of human papillomavirus type 6 in paraffin-embedded tissue sections of one condyloma acuminatum and one Buschke-Loewenstein tumour. Rübben, A., Spelten, B., Albrecht, J., Grussendorf-Conen, E.I. J. Pathol. (1994) [Pubmed]
  2. Clinical and molecular responses in high-grade intraepithelial neoplasia treated with topical imiquimod 5%. Diaz-Arrastia, C., Arany, I., Robazetti, S.C., Dinh, T.V., Gatalica, Z., Tyring, S.K., Hannigan, E. Clin. Cancer Res. (2001) [Pubmed]
  3. Efficient self-assembly of human papillomavirus type 16 L1 and L1-L2 into virus-like particles. Kirnbauer, R., Taub, J., Greenstone, H., Roden, R., Dürst, M., Gissmann, L., Lowy, D.R., Schiller, J.T. J. Virol. (1993) [Pubmed]
  4. Detection of human papillomavirus L1 protein in condylomata acuminata from various anatomical sites. Wools, K., Bryan, J.T., Katz, B.P., Rodriguez, M., Davis, T., Brown, D.R. Sexually transmitted diseases. (1994) [Pubmed]
  5. Use of human papillomavirus type 11 virions in an ELISA to detect specific antibodies in humans with condylomata acuminata. Bonnez, W., Da Rin, C., Rose, R.C., Reichman, R.C. J. Gen. Virol. (1991) [Pubmed]
  6. The acetic acid test in evaluation of subclinical genital papillomavirus infection: a comparative study on penoscopy, histopathology, virology and scanning electron microscopy findings. Wikström, A., Hedblad, M.A., Johansson, B., Kalantari, M., Syrjänen, S., Lindberg, M., von Krogh, G. Genitourinary medicine. (1992) [Pubmed]
  7. Oral cancer risk in relation to sexual history and evidence of human papillomavirus infection. Schwartz, S.M., Daling, J.R., Doody, D.R., Wipf, G.C., Carter, J.J., Madeleine, M.M., Mao, E.J., Fitzgibbons, E.D., Huang, S., Beckmann, A.M., McDougall, J.K., Galloway, D.A. J. Natl. Cancer Inst. (1998) [Pubmed]
  8. Intramuscular human interferon-beta injections in treatment of condylomata acuminata. Schonfeld, A., Nitke, S., Schattner, A., Wallach, D., Crespi, M., Hahn, T., Levavi, H., Yarden, O., Shoham, J., Doerner, T. Lancet (1984) [Pubmed]
  9. Human c-myb is expressed in cervical carcinomas and transactivates the HPV-16 promoter. Nürnberg, W., Artuc, M., Nawrath, M., Lovric, J., Stüting, S., Moelling, K., Czarnetzki, B.M., Schadendorf, D. Cancer Res. (1995) [Pubmed]
  10. Combined surgery and cidofovir is an effective treatment for genital warts in HIV-infected patients. Orlando, G., Fasolo, M.M., Beretta, R., Merli, S., Cargnel, A. AIDS (2002) [Pubmed]
  11. Overriding of cyclin-dependent kinase inhibitors by high and low risk human papillomavirus types: evidence for an in vivo role in cervical lesions. Zehbe, I., Rätsch, A., Alunni-Fabbroni, M., Burzlaff, A., Bakos, E., Dürst, M., Wilander, E., Tommasino, M. Oncogene (1999) [Pubmed]
  12. The revival of nitric acid for the treatment of anogenital warts. Heaton, C.L., Lichti, H.F., Weiner, M. Clin. Pharmacol. Ther. (1993) [Pubmed]
  13. HPV-associated flat penile lesions in men of a non-STD hospital population: less frequent and smaller in size than in male sexual partners of women with CIN. Bleeker, M.C., Hogewoning, C.J., Voorhorst, F.J., van den Brule, A.J., Berkhof, J., Hesselink, A.T., Lettink, M., Starink, T.M., Stoof, T.J., Snijders, P.J., Meijer, C.J. Int. J. Cancer (2005) [Pubmed]
  14. Eutectic lidocaine/prilocaine cream. A review of the topical anaesthetic/analgesic efficacy of a eutectic mixture of local anaesthetics (EMLA). Buckley, M.M., Benfield, P. Drugs (1993) [Pubmed]
  15. The demographics of anal cancers are changing. Identification of a high-risk population. Wexner, S.D., Milsom, J.W., Dailey, T.H. Dis. Colon Rectum (1987) [Pubmed]
  16. Increased telomerase activity and decreased telomere length in genital condylomata acuminata. Rahat, M.A., Lahat, N., Sharon, A., Gazawi, H., Abramovici, H., Bornstein, J. International journal of STD & AIDS. (1999) [Pubmed]
  17. Reduction of cell mediated immunity in patients with genital warts of long duration. Avgerinou, G., Georgala, S., Theodoridis, A., Vareltzdis, A., Stratigos, J. Genitourinary medicine. (1986) [Pubmed]
  18. Oral isotretinoin in the treatment of recalcitrant condylomata acuminata of the cervix: a randomised placebo controlled trial. Georgala, S., Katoulis, A.C., Georgala, C., Bozi, E., Mortakis, A. Sexually transmitted infections. (2004) [Pubmed]
  19. Simultaneously detected aberrant p53 tumor suppressor protein and HPV-DNA localize mostly in separate keratinocytes in anogenital and common warts. Lassus, J., Ranki, A. Exp. Dermatol. (1996) [Pubmed]
  20. Subclinical human papilloma virus infection in condylomata acuminata patients attending a VD clinic. Sand Petersen, C., Albrectsen, J., Larsen, J., Sindrup, J., Tikjøb, G., Ottevanger, V., Karlsmark, T., Fogh, H., Mellon Mogensen, A., Wolff-Sneedorff, A. Acta Derm. Venereol. (1991) [Pubmed]
  21. Local anaesthesia with a lidocaine/prilocaine cream (EMLA) for cautery of condylomata acuminata on the vulval mucosa. The effect of timing of application of the cream. Ljunghall, K., Lillieborg, S. Acta Derm. Venereol. (1989) [Pubmed]
  22. Characterization of HPV16 L1 loop domains in the formation of a type-specific, conformational epitope. Olcese, V.A., Chen, Y., Schlegel, R., Yuan, H. BMC Microbiol. (2004) [Pubmed]
  23. A randomized phase II study comparing four different interferon therapies in patients with recalcitrant condylomata acuminata. Trizna, Z., Evans, T., Bruce, S., Hatch, K., Tyring, S.K. Sexually transmitted diseases. (1998) [Pubmed]
  24. Identification of immunoreactive antigens of human papillomavirus type 6b by using Escherichia coli-expressed fusion proteins. Jenison, S.A., Firzlaff, J.M., Langenberg, A., Galloway, D.A. J. Virol. (1988) [Pubmed]
  25. Condylomata acuminata in IDDM. Bell, D.S., Clements, R.S., Cutter, G.R., Whitley, R.J. Diabetes Care (1988) [Pubmed]
  26. Inhibition of papilloma progression by antisense oligonucleotides targeted to HPV11 E6/E7 RNA. Clawson, G.A., Miranda, G.Q., Sivarajah, A., Xin, P., Pan, W., Thiboutot, D., Christensen, N.D. Gene Ther. (2004) [Pubmed]
  27. Combination of laser-therapy with 0.5% idoxuridine cream in the treatment of therapy-resistant genital warts in male patients: an open study. Happonen, H.P., Lassus, A., Santalahti, J., Forsstrom, S., Lassus, J. Sexually transmitted diseases. (1990) [Pubmed]
  28. Treatment of external genital warts comparing cryotherapy (liquid nitrogen) and trichloroacetic acid. Abdullah, A.N., Walzman, M., Wade, A. Sexually transmitted diseases. (1993) [Pubmed]
  29. Antibodies to human papillomavirus type 11 virus-like particles in sera of patients with genital warts and in control groups. Eisemann, C., Fisher, S.G., Gross, G., Müller, M., Gissmann, L. J. Gen. Virol. (1996) [Pubmed]
  30. Antibody response to human papillomavirus (HPV) type 11 in children with juvenile-onset recurrent respiratory papillomatosis (RRP). Bonnez, W., Kashima, H.K., Leventhal, B., Mounts, P., Rose, R.C., Reichman, R.C., Shah, K.V. Virology (1992) [Pubmed]
  31. Colposcopic evaluation of men with genital warts. Comite, S.L., Castadot, M.J. J. Am. Acad. Dermatol. (1988) [Pubmed]
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