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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Peripheral beta-adrenergic blockade treatment of parkinsonian tremor.

The effect of nadolol, a peripherally acting beta-adrenergic blocker, on resting, postural, and intention tremor was examined in 8 patients with idiopathic Parkinson's disease whose motor symptoms, other than tremor, were well controlled with conventional medications. In a double-blind, placebo-controlled, crossover design, patients received 80 to 320 mg of nadolol for six weeks while continuing their previous therapeutic regimen. Accelerometer readings showed a 34% reduction (p less than 0.025) in tremor distance, but no change in tremor frequency, during nadolol therapy. Maximum benefit was achieved with a dose of 240 mg, when resting tremor improved 54%, postural tremor 32%, and intention tremor 54%. Physician ratings and patient reports supported the accelerometer results. Nadolol appears to be a safe, effective adjunct to current dopaminergic and anticholinergic therapy for severe tremor in Parkinson's disease.[1]


  1. Peripheral beta-adrenergic blockade treatment of parkinsonian tremor. Foster, N.L., Newman, R.P., LeWitt, P.A., Gillespie, M.M., Larsen, T.A., Chase, T.N. Ann. Neurol. (1984) [Pubmed]
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