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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Transglutaminase is essential in receptor- mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones.

The receptor-mediated endocytosis of alpha 2-macroglobulin can be inhibited by a diverse group of chemical compounds all of which share the property of being inhibitors of one form of cellular transglutaminase. The present results strongly suggest that protein cross-linking may be essential for receptor-mediated endocytosis of some protein and polypeptide hormones.[1]


  1. Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones. Davies, P.J., Davies, D.R., Levitzki, A., Maxfield, F.R., Milhaud, P., Willingham, M.C., Pastan, I.H. Nature (1980) [Pubmed]
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