Activated T lymphocytes in patients with multiple sclerosis.
We used four monoclonal antibodies designated MLR-1, -2, -3, and -4, specifically directed against determinants uniquely present on activated T lymphocytes to analyze peripheral blood lymphocytes (PBL) of patients with multiple sclerosis ( MS). By indirect immunofluorescence techniques, we found that many PBL expressed one or more of these activation antigens. Thus, high percentages of MLR-2 positive cells were found in all 20 MS patients (66 +/- 12% in 13 patients with the remitting form and 57 +/- 14% in 7 patients with the progressive form). MLR-3 positive cells were found in three patients with the remitting form and five patients with progressive MS, MLR-4 in seven patients with remitting MS and in five with the progressive type. MLR-1 positive cells were prominent in only two cases (one remitting and one progressive). Discrepancies between expression of MLR antigens and molecules coded by the HLA-DR region (Ia antigens) were observed.[1]References
- Activated T lymphocytes in patients with multiple sclerosis. Golaz, J., Steck, A., Moretta, L. Neurology (1983) [Pubmed]
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