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Gene Review:

LCORL - ligand dependent nuclear receptor...

Homo sapiens

Synonyms: FLJ30696, LCoR-like protein, Ligand-dependent nuclear receptor corepressor-like protein, MLR1

Rogers, M.L. et al., Golaz, J. et al., Corte, G. et al., Kunieda, T. et al.

Rogers, Atmosukarto, Berhanu, Matusica, Macardle, Rush,

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Disease relevance of LCORL

We used four monoclonal antibodies designated MLR-1, -2, -3, and -4, specifically directed against determinants uniquely present on activated T lymphocytes to analyze peripheral blood lymphocytes (PBL) of patients with multiple sclerosis (MS) [1].

High impact information on LCORL

Thus, MLR2 stains nearly all the responder T cells present in a secondary MLR, while MLR 1, 3 and 4 stain only a fraction [2].
Mlr1 transcripts were lost in the testis of W/W(v) mutant mice, suggesting a role in spermatogenesis [3].
Both MLR1 and MLR2 partially blocked NGF induced cell death in a mouse cell-line that expresses p75NTR but not TrKA [4].

Analytical, diagnostic and therapeutic context of LCORL

MLR1 and MLR2 bound to human p75NTR with higher affinity than the well-characterized ME20.4 in ELISA and also recognized p75NTR present on neurons in both rat and mouse [4].

References

Activated T lymphocytes in patients with multiple sclerosis. Golaz, J., Steck, A., Moretta, L. Neurology (1983) [Pubmed]
Surface antigens specifically expressed by activated T cells in humans. Corte, G., Moretta, L., Damiani, G., Mingari, M.C., Bargellesi, A. Eur. J. Immunol. (1981) [Pubmed]
Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain(1). Kunieda, T., Park, J.M., Takeuchi, H., Kubo, T. FEBS Lett. (2003) [Pubmed]
Functional monoclonal antibodies to p75 neurotrophin receptor raised in knockout mice. Rogers, M.L., Atmosukarto, I., Berhanu, D.A., Matusica, D., Macardle, P., Rush, R.A. J. Neurosci. Methods (2006) [Pubmed]

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LCORL	Bos taurus
lcorl	Danio rerio
LCORL	Gallus gallus
LCORL	Macaca mulatta
Lcorl	Mus musculus
LCORL	Pan troglodytes
Lcorl	Rattus norvegicus

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