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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Time-course of actinomycin D inhibition of tobacco mosaic virus multiplication relative to the rate of spread of the infection.

The time-course of inhibition of tobacco mosaic virus synthesis in mechanically inoculated leaves by actinomycin D was not correlated with cell-to-cell spread of the infection, as previously shown to be the case with 2-thiouracil and guanidine inhibition. The amount of inhibition by actinomycin D declined after inoculation much more rapidly than the infection spread. An actinomycin-D-sensitive step or its product occurred in cells before they became infected.[1]


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