A gene chimaera of SV40 and mouse beta-globin is transcribed and properly spliced.
A gene chimaera of the first exon from simian virus 40 (SV40) sequences coding for T antigen placed upstream from the third exon from mouse beta-globin, and separated by the resultant new chimaeric intron, was cloned into a bacterial plasmid. When transfected into monkey cells, the gene chimaera was transcribed, polyadenylated and spliced using the donor splice site from SV40 and the acceptor splice site from mouse beta-globin. This result suggests that a donor site from one gene can be spliced to an acceptor site from another gene.[1]References
- A gene chimaera of SV40 and mouse beta-globin is transcribed and properly spliced. Chu, G., Sharp, P.A. Nature (1981) [Pubmed]
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