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MeSH Review

Simian virus 40

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Disease relevance of Simian virus 40


Psychiatry related information on Simian virus 40

  • This study characterizes four private idiotypes (Id) associated with monoclonal antibodies (mAb) to simian virus 40 (SV40) tumor antigen (T-Ag), and to a cellular protein, p53 [6].

High impact information on Simian virus 40

  • Following transport of the caveolar protein Caveolin-1 and two cargo complexes, Simian Virus 40 and Cholera toxin, in live cells, we uncovered a Rab5-dependent pathway in which caveolar vesicles are targeted to early endosomes and form distinct and stable membrane domains [7].
  • Large T antigen, the regulatory protein encoded by simian virus 40, has DNA helicase activity and unwinds double-stranded DNA at the expense of ATP [8].
  • Treatment of SV40 virus infected monkey cells with m-AMSA resulted in both single- and double-stranded breaks on SV40 viral chromatin [9].
  • Deletion and substitution mutations in the control region of simian virus 40 (SV40) were used to study regulation of early transcription by T antigen [10].
  • Extensive work on the maturation of lagging strands during the replication of simian virus 40 DNA suggests that the initiator RNA primers of Okazaki fragments are removed by the combined action of two nucleases, RNase HI and Fen1, before the Okazaki fragments join [11].

Chemical compound and disease context of Simian virus 40


Biological context of Simian virus 40

  • A gene chimaera of the first exon from simian virus 40 (SV40) sequences coding for T antigen placed upstream from the third exon from mouse beta-globin, and separated by the resultant new chimaeric intron, was cloned into a bacterial plasmid [17].
  • Several reports have implicated p53 in mammalian cell cycle control and specifically with events occurring at the G0-G1 boundary. p53 forms specific complexes with simian virus 40 (SV40) large-T antigen, and such complexes are found associated with both replicating and mature SV40 DNA in lytically infected cells [18].
  • The protein was first identified by its specific immunological cross reaction with the simian virus 40 large T antigen, the transforming protein of a small DNA tumour virus [19].
  • The simian virus 40 (SV40) early gene product large T antigen promiscuously activates simple promoters containing a TATA box or initiator element and at least one upstream transcription factor-binding site [20].
  • Replication of simian virus 40 (SV40) DNA is dependent upon the binding of the viral T-antigen to the SV40 origin of replication [21].

Anatomical context of Simian virus 40


Gene context of Simian virus 40


Analytical, diagnostic and therapeutic context of Simian virus 40


  1. Absence of nucleosomes in a histone-containing nucleoprotein complex obtained by dissociation of purified SV40 virions. Moyne, G., Harper, F., Saragosti, S., Yaniv, M. Cell (1982) [Pubmed]
  2. Resolution of simian virus 40 proteins in whole cell extracts by two-dimensional electrophoresis: heterogeneity of the major capsid protein. O'Farrell, P.Z., Goodman, H.M. Cell (1976) [Pubmed]
  3. Expression of the HTLV-III envelope gene by a recombinant vaccinia virus. Chakrabarti, S., Robert-Guroff, M., Wong-Staal, F., Gallo, R.C., Moss, B. Nature (1986) [Pubmed]
  4. Simian virus 40 enhancer increases RNA polymerase density within the linked gene. Weber, F., Schaffner, W. Nature (1985) [Pubmed]
  5. Induction of tumor antigen-specific immunity in vivo by a novel vaccinia vector encoding safety-modified simian virus 40 T antigen. Xie, Y.C., Hwang, C., Overwijk, W., Zeng, Z., Eng, M.H., Mulé, J.J., Imperiale, M.J., Restifo, N.P., Sanda, M.G. J. Natl. Cancer Inst. (1999) [Pubmed]
  6. Suppression of in vivo tumor formation induced by simian virus 40-transformed cells in mice receiving antiidiotypic antibodies. Kennedy, R.C., Dreesman, G.R., Butel, J.S., Lanford, R.E. J. Exp. Med. (1985) [Pubmed]
  7. Caveolin-stabilized membrane domains as multifunctional transport and sorting devices in endocytic membrane traffic. Pelkmans, L., Bürli, T., Zerial, M., Helenius, A. Cell (2004) [Pubmed]
  8. RNA unwinding activity of SV40 large T antigen. Scheffner, M., Knippers, R., Stahl, H. Cell (1989) [Pubmed]
  9. In vivo mapping of DNA topoisomerase II-specific cleavage sites on SV40 chromatin. Yang, L., Rowe, T.C., Nelson, E.M., Liu, L.F. Cell (1985) [Pubmed]
  10. SV40 T antigen binding site mutations that affect autoregulation. Rio, D.C., Tjian, R. Cell (1983) [Pubmed]
  11. RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes. Bae, S.H., Bae, K.H., Kim, J.A., Seo, Y.S. Nature (2001) [Pubmed]
  12. Interaction between CD4 and class II MHC molecules mediates cell adhesion. Doyle, C., Strominger, J.L. Nature (1987) [Pubmed]
  13. Simian virus 40 crystals. Lattman, E.E. Science (1980) [Pubmed]
  14. Regulation of methionine adenosyltransferase in normal diploid and simian virus 40-transformed human fibroblasts. Jacobsen, S.J., Hoffman, R.M., Erbe, R.W. J. Natl. Cancer Inst. (1980) [Pubmed]
  15. Tumor virus induction and host cell capacity inactivation: possible in vitro tests for photosensitizing chemicals. Bockstahler, L.E., Coohill, T.P., Lytle, C.D., Moore, S.P., Cantwell, J.M., Schmidt, B.J. J. Natl. Cancer Inst. (1982) [Pubmed]
  16. Study of liver differentiation in vitro. Chou, J.Y., Schlegel-Haueter, S.E. J. Cell Biol. (1981) [Pubmed]
  17. A gene chimaera of SV40 and mouse beta-globin is transcribed and properly spliced. Chu, G., Sharp, P.A. Nature (1981) [Pubmed]
  18. Mouse p53 inhibits SV40 origin-dependent DNA replication. Braithwaite, A.W., Sturzbecher, H.W., Addison, C., Palmer, C., Rudge, K., Jenkins, J.R. Nature (1987) [Pubmed]
  19. RNA helicase activity associated with the human p68 protein. Hirling, H., Scheffner, M., Restle, T., Stahl, H. Nature (1989) [Pubmed]
  20. TAF-like function of SV40 large T antigen. Damania, B., Alwine, J.C. Genes Dev. (1996) [Pubmed]
  21. Localized melting and structural changes in the SV40 origin of replication induced by T-antigen. Borowiec, J.A., Hurwitz, J. EMBO J. (1988) [Pubmed]
  22. Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferon. Pober, J.S., Collins, T., Gimbrone, M.A., Cotran, R.S., Gitlin, J.D., Fiers, W., Clayberger, C., Krensky, A.M., Burakoff, S.J., Reiss, C.S. Nature (1983) [Pubmed]
  23. Structure and expression of a cloned cDNA for human interleukin-2. Taniguchi, T., Matsui, H., Fujita, T., Takaoka, C., Kashima, N., Yoshimoto, R., Hamuro, J. Nature (1983) [Pubmed]
  24. Subcellular distribution of the tumor-specific transplantation antigen of simian virus 40-transformed cells. Rogers, M.J., Law, L.W., Appella, E. J. Natl. Cancer Inst. (1977) [Pubmed]
  25. Establishment of micrometastatic carcinoma cell lines: a novel source of tumor cell vaccines. Pantel, K., Dickmanns, A., Zippelius, A., Klein, C., Shi, J., Hoechtlen-Vollmar, W., Schlimok, G., Weckermann, D., Oberneder, R., Fanning, E. J. Natl. Cancer Inst. (1995) [Pubmed]
  26. Expression of SV40 virus large T antigen by recombinant adenoviruses activates proliferation of corneal endothelium in vitro. Feldman, S.T., Gjerset, R., Gately, D., Chien, K.R., Feramisco, J.R. J. Clin. Invest. (1993) [Pubmed]
  27. SV40 T antigen interacts with Nbs1 to disrupt DNA replication control. Wu, X., Avni, D., Chiba, T., Yan, F., Zhao, Q., Lin, Y., Heng, H., Livingston, D. Genes Dev. (2004) [Pubmed]
  28. Role of c-myc in simian virus 40 large tumor antigen-induced DNA synthesis in quiescent 3T3-L1 mouse fibroblasts. Hermeking, H., Wolf, D.A., Kohlhuber, F., Dickmanns, A., Billaud, M., Fanning, E., Eick, D. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  29. E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product. Flemington, E.K., Speck, S.H., Kaelin, W.G. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  30. Synthesis of DNA containing the simian virus 40 origin of replication by the combined action of DNA polymerases alpha and delta. Lee, S.H., Eki, T., Hurwitz, J. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  31. Adeno-associated viral vector-mediated hypoxia response element-regulated gene expression in mouse ischemic heart model. Su, H., Arakawa-Hoyt, J., Kan, Y.W. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  32. Evidence for an intermediate with a single-strand break in the reaction catalyzed by the DNA untwisting enzyme. Champoux, J.J. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  33. The simian virus 40 small-t intron, present in many common expression vectors, leads to aberrant splicing. Huang, M.T., Gorman, C.M. Mol. Cell. Biol. (1990) [Pubmed]
  34. Immortalization-susceptible elements and their binding factors mediate rejuvenation of regulation of the type I collagenase gene in simian virus 40 large T antigen-transformed immortal human fibroblasts. Imai, S., Fujino, T., Nishibayashi, S., Manabe, T., Takano, T. Mol. Cell. Biol. (1994) [Pubmed]
  35. Biological and biochemical properties of soluble tumor-specific transplantation antigen of a simian virus 40-induced neoplasm. Appella, E., Law, L.W., Henriksen, O. Cancer Res. (1976) [Pubmed]
  36. Neuronal and glial properties of a murine transgenic retinoblastoma model. Kivelä, T., Virtanen, I., Marcus, D.M., O'Brien, J.M., Carpenter, J.L., Brauner, E., Tarkkanen, A., Albert, D.M. Am. J. Pathol. (1991) [Pubmed]
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