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Penney, J.B. et al.

Quantitative autoradiography of [3H]muscimol binding in rat brain.

A simple quantitative autoradiographic technique for the study of neurotransmitter receptors that includes the use of a tritium-sensitive film permits saturation, kinetic, and competition studies of brain samples as small as 0.01 cubic millimeter. This technique was used to study [3H]muscimol binding in rat brain. Unilateral gamma-aminobutyric acid receptor supersensitivity was observed in the substantia nigra pars reticulata after production of localized lesions of the ipsilateral corpus striatum.[1]

References

Quantitative autoradiography of [3H]muscimol binding in rat brain. Penney, J.B., Pan, H.S., Young, A.B., Frey, K.A., Dauth, G.W. Science (1981) [Pubmed]

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