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Chemical Compound Review

TRITIUM     molecular hydrogen

Synonyms: tritio, Hydrogen-3, CHEBI:29238, AC1L3OSZ, (3)H, ...
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Disease relevance of TRITIUM


High impact information on TRITIUM

  • Acrylamide gel electrophoresis of the proteins from HeLa cells labeled with 3H-arginine during S phase showed that the core histones were labeled preferentially, constituting 30% of the total cellular tritium and 50% of the label in a crude nuclear fraction [6].
  • The phenylalanine hydroxylase activity in this child, as determined by an in vivo tritium-release assay, was 2.3 per cent of the normal value [7].
  • In binding assays with membranes from guinea pig brain, ethylketocyclazocine and dynorphin-(1--13) amide were more potent in displacing tritium-labeled ethylketocyclazocine than in displacing typical mu and delta opioid receptor ligands [8].
  • A radioimmunoassay for the detection of antibodies in human serum to tritium-labeled HeLa cell cytoplasmic ribosomes was developed with the use of Macaloid for the inhibition of endogenous ribonuclease activity [9].
  • Mouse spleen cells capable of specifically binding intrinsically tritium-labeled polymerized flagellin (POL) (labeling by biosynthesis of flagellar protein) via IgM receptors were found to comprise a distinct population of about 20-50 cells per 10(6) lymphocytes [10].

Chemical compound and disease context of TRITIUM


Biological context of TRITIUM


Anatomical context of TRITIUM


Associations of TRITIUM with other chemical compounds


Gene context of TRITIUM

  • A tritium-labeled aminoterminal heptapeptide of SP, 3H-SP(1-7), was synthesized, purified, and used to characterize the binding of a variety of fragments of SP and opioids in the mouse brain and spinal cord membranes [30].
  • The determination of CD28-costimulated cell proliferation was performed by tritium uptake, cytokine production by ELISA, cell surface interleukin 2Ra and CD69 expression by flow cytometry, and mixed leukocyte reaction by tritium uptake [31].
  • 2. Somatostatin stimulated tritium release (pEC(50)) through the sst(2) (7.8+/-0.1) and sst(5) (7.3+/-0.2), but not the sst(3) receptor [32].
  • The data presented in this manuscript describes the binding characteristics of [3H]SB 209670, a potent nonpeptide tritium-labeled endothelin (ET) receptor antagonist [33].
  • Several recombinant human P450 enzymes were incubated with [1,2,6,7-3H]testosterone, and only cDNA-expressed CYP3A4 catalyzed a high rate of tritium release [34].

Analytical, diagnostic and therapeutic context of TRITIUM

  • Uptake of a tritium-labeled amine through these channels can be measured by autoradiography [35].
  • Electrical stimulation produced frequency-dependent increases in the tritium efflux and in the contractions [36].
  • Evidence is presented that the majority of mouse spleen cells binding tritium-labeled POL undergoes blastogenesis after antigen capping, antigen shedding, and receptor reformation [10].
  • The initial diagnosis of i(18p) was by standard cytogenetic techniques and was confirmed by in situ hybridization with a biotinylated alphoid probe (L1.84) specific for the pericentric region of chromosome 18 and with a tritium-labeled chromosome 18 probe (B74) which hybridizes to the D18S3 locus situated at 18p11 [37].
  • By means of the fast gel filtration column techniques originally developed for tritium exchange experiments, we were able to replace the solvent of a tRNA sample from an 1H2O to an 2H2O buffer and obtain a useful spectrum in 2-5 min [38].


  1. Measles virus nucleotide sequences: detection by hybridization in situ. Haase, A.T., Ventura, P., Gibbs, C.J., Tourtellotte, W.W. Science (1981) [Pubmed]
  2. Nonenzymatic glycosylation of erythrocyte membrane proteins. Relevance to diabetes. Miller, J.A., Gravallese, E., Bunn, H.F. J. Clin. Invest. (1980) [Pubmed]
  3. Antibodies to ribosomes in chronic active hepatitis. Gerber, M.A., Shapiro, J.M., Smith, H., Lebwohl, O., Schaffner, F. Gastroenterology (1979) [Pubmed]
  4. Comparison of the structures of free and ribosome-bound tRNAPhe by using slow tritium exchange. Farber, N., Cantor, C.R. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  5. Spatially localized generation of nucleotide sequence-specific DNA damage. Oh, D.H., King, B.A., Boxer, S.G., Hanawalt, P.C. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  6. Arginine-rich histones do not exchange between human and mouse chromosomes in hybrid cells. Manser, T., Thacher, T., Rechsteiner, M. Cell (1980) [Pubmed]
  7. Hyperphenylalaninemia due to a deficiency of biopterin. A variant form of phenylketonuria. Kaufman, S., Berlow, S., Summer, G.K., Milstien, S., Schulman, J.D., Orloff, S., Spielberg, S., Pueschel, S. N. Engl. J. Med. (1978) [Pubmed]
  8. Dynorphin is a specific endogenous ligand of the kappa opioid receptor. Chavkin, C., James, I.F., Goldstein, A. Science (1982) [Pubmed]
  9. Radioimmunoassay for antibodies to cytoplasmic ribosomes in human serum. Koffler, D., Faiferman, I., Gerber, M.A. Science (1977) [Pubmed]
  10. Antigen recognition. IV. Discrimination by antigen-binding immunocompetent B cells between immunity and tolerance is determined by adherent cells. Diener, E., Kraft, N., Lee, K.C., Shiozawa, C. J. Exp. Med. (1976) [Pubmed]
  11. Interaction between endotoxin and human monocytes: characteristics of the binding of 3H-labeled lipopolysaccharide and 51Cr-labeled lipid A before and after the induction of endotoxin tolerance. Larsen, N.E., Sullivan, R. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  12. Upregulation of serum retinol in experimental acute renal failure. Gerlach, T.H., Zile, M.H. FASEB J. (1990) [Pubmed]
  13. Cellular pharmacology of dichloro(ethylenediamine)platinum(II) in cisplatin-sensitive and resistant human ovarian carcinoma cells. Jekunen, A.P., Hom, D.K., Alcaraz, J.E., Eastman, A., Howell, S.B. Cancer Res. (1994) [Pubmed]
  14. Metabolic fate of 3,4-dihydroxybutyl-1-phosphonate in Escherichia coli. Tyhach, R.J., Engel, R., Tropp, B.E. J. Biol. Chem. (1976) [Pubmed]
  15. Apparent dispensability of the carbohydrate moiety of human interferon for antiviral activity. Bose, S., Gurari-Rotman, D., Ruegg, U.T., Corley, L., Anfinsen, C.B. J. Biol. Chem. (1976) [Pubmed]
  16. Incorporation of tritiated uridine into DNA of Ehrlich ascites tumor cells. Yost, B.K., Rosenberg, M.J., Nishioka, D.J. J. Natl. Cancer Inst. (1976) [Pubmed]
  17. Albumin absorption and catabolism by isolated perfused proximal convoluted tubules of the rabbit. Park, C.H., Maack, T. J. Clin. Invest. (1984) [Pubmed]
  18. Centrally administered bombesin affects gastric emptying and small and large bowel transit in the rat. Porreca, F., Burks, T.F. Gastroenterology (1983) [Pubmed]
  19. Intestinal absorption of [3H]folic acid in the chronic alcoholic monkey. Romero, J.J., Tamura, T., Halsted, C.H. Gastroenterology (1981) [Pubmed]
  20. The transcription cycle of RNA polymerase II in living cells. Kimura, H., Sugaya, K., Cook, P.R. J. Cell Biol. (2002) [Pubmed]
  21. Neoplastic and life-span effects of chronic exposure to tritium. I. Effects on adult rats exposed during pregnancy. Cahill, D.F., Wright, J.F., Godbold, J.H., Ward, J.M., Laskey, J.W., Tompkins, E.A. J. Natl. Cancer Inst. (1975) [Pubmed]
  22. Effects of butylated hydroxyanisole on the metabolism of benzo[a]pyrene by mouse liver microsomes. Lam, L.K., Wattenberg, L.W. J. Natl. Cancer Inst. (1977) [Pubmed]
  23. Resolution of cellular compartments involved in membrane potential changes accompanying IgE-mediated degranulation of rat basophilic leukemia cells. Sagi-Eisenberg, R., Pecht, I. EMBO J. (1984) [Pubmed]
  24. Dynamic behavior of histone H1 microinjected into HeLa cells. Wu, L.H., Kuehl, L., Rechsteiner, M. J. Cell Biol. (1986) [Pubmed]
  25. Effect of sulfonylureas on triglyceride metabolism in the rat liver: possible role of the lysosomes in hepatic lipolysis. Debeer, L.J., Thomas, J., Mannaerts, G., DeSchepper, P.J. J. Clin. Invest. (1977) [Pubmed]
  26. Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors. Hirota, S., Ohashi, A., Nishida, T., Isozaki, K., Kinoshita, K., Shinomura, Y., Kitamura, Y. Gastroenterology (2003) [Pubmed]
  27. Increased expression of MAP KINASE KINASE7 causes deficiency in polar auxin transport and leads to plant architectural abnormality in Arabidopsis. Dai, Y., Wang, H., Li, B., Huang, J., Liu, X., Zhou, Y., Mou, Z., Li, J. Plant Cell (2006) [Pubmed]
  28. Interaction of phosphatidylserine with mast cells. Martin, T.W., Lagunoff, D. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  29. Endogenous leukotriene D4 formation during anaphylactic shock in the guinea pig. Keppler, A., Orning, L., Bernström, K., Hammarström, S. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  30. Specific binding of substance P aminoterminal heptapeptide [SP(1-7)] to mouse brain and spinal cord membranes. Igwe, O.J., Kim, D.C., Seybold, V.S., Larson, A.A. J. Neurosci. (1990) [Pubmed]
  31. Plant alkaloid tetrandrine and its analog block CD28-costimulated activities of human peripheral blood T cells: potential immunosuppressants in transplantation immunology. Lai, J.H., Ho, L.J., Kwan, C.Y., Chang, D.M., Lee, T.C. Transplantation (1999) [Pubmed]
  32. Somatostatin receptor-mediated arachidonic acid mobilization: evidence for partial agonism of synthetic peptides. Alderton, F., Fan, T.P., Humphrey, P.P. Br. J. Pharmacol. (2001) [Pubmed]
  33. Nonpeptide endothelin receptor antagonists. VII: Binding characteristics of [3H]SB 209670, a novel nonpeptide antagonist of endothelin receptors. Nambi, P., Pullen, M., Wu, H.L., Lee, D., Saunders, D., Heys, R., Aiyar, N., Leber, J., Elliott, J., Brooks, D., Ohlstein, E., Ruffolo, R. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  34. Development of a non-high pressure liquid chromatography assay to determine testosterone hydroxylase (CYP3A) activity in human liver microsomes. Draper, A.J., Madan, A., Smith, K., Parkinson, A. Drug Metab. Dispos. (1998) [Pubmed]
  35. Transmitter sensitivity of neurons assayed by autoradiography. Yoshikami, D. Science (1981) [Pubmed]
  36. [Release of gamma-aminobutyric acid from cat colon.]. Taniyama, K., Kusunoki, M., Saito, N., Tanaka, C. Science (1982) [Pubmed]
  37. The isochromosome 18p syndrome: confirmation of cytogenetic diagnosis in nine cases by in situ hybridization. Callen, D.F., Freemantle, C.J., Ringenbergs, M.L., Baker, E., Eyre, H.J., Romain, D., Haan, E.A. Am. J. Hum. Genet. (1990) [Pubmed]
  38. Real-time solvent exchange studies of the imino and amino protons of yeast phenylalanine transfer RNA by Fourier transform NMR. Johnston, P.D., Figueroa, N., Redfield, A.G. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
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