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Richardson, J.S. et al.

Naloxone and self-mutilation.

A 15-year-old male with a long history of self-mutilation resembling the Lesch-Nyhan syndrome, but with normal uric acid levels, was treated with naloxone. Pain-inducing behavior decreased in the evenings following infusion of the drug, and was markedly reduced for 2 days following the treatment period. Though not recommended as therapy, the observations suggest that naloxone may play a role in the regulation of endorphin/enkephalin neural systems.[1]

References

Naloxone and self-mutilation. Richardson, J.S., Zaleski, W.A. Biol. Psychiatry (1983) [Pubmed]

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