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MeSH Review

Self Mutilation

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Disease relevance of Self Mutilation


Psychiatry related information on Self Mutilation


High impact information on Self Mutilation

  • Both self-mutilation and impulsivity showed significant negative correlations with Bmax, although the two groups did not differ in CSF 5-HIAA levels or in platelet imipramine binding [8].
  • A more intensive study was done of another individual who committed murder and self-mutilation under the influence of PCP [9].
  • It is manifest by behavioral abnormalities, including self-mutilation, and evidence of abnormal 3,4-dihydroxyphenylethylamine (dopamine) metabolism [10].
  • It appears, therefore, that the caffeine model is not a true model for the Lesch-Nyhan syndrome, or alternatively, that the deficit in hypoxanthine-guanine phosphoribosyltransferase is coincidental and not a main key to the multifarious aspects of the syndrome, particularly the self-mutilation [11].
  • These behaviors typically involved an oral component and included grooming and mouthing following SKF-38393 in depleted 10-day-old pups, mouthing following administration of either agonist to depleted weanlings, and probing and intense self-mutilation (forepaw and tongue biting) following the combined agonists in depleted weanlings [12].

Chemical compound and disease context of Self Mutilation


Anatomical context of Self Mutilation

  • A further role for central mechanisms was indicated since referred hyperalgesia--the enhancement of self-mutilation (autotomy) of a denervated limb which had previously sustained a heat injury--was reduced by spinal anesthesia or a combined blocking of C-fiber afferents and sympathetic efferents with intrathecal capsaicin + guanethidine [18].

Gene context of Self Mutilation


Analytical, diagnostic and therapeutic context of Self Mutilation

  • Although 3 patients experienced self-mutilation, no consistent abnormalities were found in the temperature-stability of their HGPRT at 4 degrees C and 70 degrees C, or in isoelectrofocusing of HGPRT purified by immunoprecipitation [24].
  • The habitual self-mutilation group had significantly higher scores on the Beck Depression Inventory-II, Bulimia Investigatory Test of Edinburgh, and Adolescent Dissociative Experience Scale than either of the two control groups (P < 0.001) [25].


  1. Expression of human HPRT in the central nervous system of transgenic mice. Stout, J.T., Chen, H.Y., Brennand, J., Caskey, C.T., Brinster, R.L. Nature (1985) [Pubmed]
  2. Double-blind clinical trial of 5-hydroxytryptophan in a case of Lesch-Nyhan syndrome. Frith, C.D., Johnston, E.C., Joseph, M.H., Powell, R.J., Watts, R.W. J. Neurol. Neurosurg. Psychiatr. (1976) [Pubmed]
  3. Naltrexone and fluoxetine in Prader-Willi syndrome. Benjamin, E., Buot-Smith, T. Journal of the American Academy of Child and Adolescent Psychiatry. (1993) [Pubmed]
  4. Molecular, biochemical, and genetic characterization of a female patient with Lesch-Nyhan disease. Rinat, C., Zoref-Shani, E., Ben-Neriah, Z., Bromberg, Y., Becker-Cohen, R., Feinstein, S., Sperling, O., Frishberg, Y. Mol. Genet. Metab. (2006) [Pubmed]
  5. Disappearance of self-mutilating behavior in a patient with lesch-nyhan syndrome after bilateral chronic stimulation of the globus pallidus internus. Case report. Taira, T., Kobayashi, T., Hori, T. J. Neurosurg. (2003) [Pubmed]
  6. Neurotransmitter changes in the pathophysiology of Lesch-Nyhan syndrome. Saito, Y., Takashima, S. Brain Dev. (2000) [Pubmed]
  7. Repetitive self-mutilation among Japanese eating disorder patients with drug use disorder: comparison with patients with methamphetamine use disorder. Nagata, T., Oshima, J., Wada, A., Yamada, H., Kiriike, N. J. Nerv. Ment. Dis. (2003) [Pubmed]
  8. Self-mutilation in personality disorders: psychological and biological correlates. Simeon, D., Stanley, B., Frances, A., Mann, J.J., Winchel, R., Stanley, M. The American journal of psychiatry. (1992) [Pubmed]
  9. Violence associated with phencyclidine abuse. Fauman, M.A., Fauman, B.J. The American journal of psychiatry. (1979) [Pubmed]
  10. Dopamine metabolism in hypoxanthine-guanine phosphoribosyltransferase-deficient variants of PC12 cells. Bitler, C.M., Howard, B.D. J. Neurochem. (1986) [Pubmed]
  11. Lesch-Nyhan syndrome, caffeine model: increase of purine and pyrimidine enzymes in rat brain. Miñana, M.D., Portolés, M., Jordá, A., Grisolía, S. J. Neurochem. (1984) [Pubmed]
  12. Effects of acute dopamine depletion on responsiveness to D1 and D2 receptor agonists in infant and weanling rat pups. Moody, C.A., Spear, L.P. Psychopharmacology (Berl.) (1992) [Pubmed]
  13. Pharmacological evaluation of SCH-12679: evidence for an in vivo antagonism of D1-dopamine receptors. Breese, G.R., Criswell, H.E., McQuade, R.D., Iorio, L.C., Mueller, R.A. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  14. Determinants of increased drug self-administration due to food deprivation. Carroll, M.E., Meisch, R.A. Psychopharmacology (Berl.) (1981) [Pubmed]
  15. Enhanced muscimol-induced behavioral responses after 6-OHDA lesions: relevance to susceptibility for self-mutilation behavior in neonatally lesioned rats. Breese, G.R., Hulebak, K.L., Napier, T.C., Baumeister, A., Frye, G., Mueller, R.A. Psychopharmacology (Berl.) (1987) [Pubmed]
  16. Autotomy following sciatic and saphenous nerve sections: sparing of the medial toes after treatment of the sciatic nerve with capsaicin. Coderre, T.J., Grimes, R.W., Melzack, R. Exp. Neurol. (1986) [Pubmed]
  17. The effect of diphenylhydantoin on self-mutilation in rats produced by unilateral multiple dorsal rhizotomy. Duckrow, R.B., Taub, A. Exp. Neurol. (1977) [Pubmed]
  18. Cutaneous hyperalgesia: contributions of the peripheral and central nervous systems to the increase in pain sensitivity after injury. Coderre, T.J., Melzack, R. Brain Res. (1987) [Pubmed]
  19. Effect of peripheral axotomy on dorsal root ganglion neuron phenotype and autonomy behaviour in neuropeptide Y-deficient mice. Shi, T.J., Zhang, X., Berge, O.G., Erickson, J.C., Palmiter, R.D., Hökfelt, T. Regul. Pept. (1998) [Pubmed]
  20. The evaluation of autonomic nervous function in a patient with hereditary sensory and autonomic neuropathy type IV with novel mutations of the TRKA gene. Ohto, T., Iwasaki, N., Fujiwara, J., Ohkoshi, N., Kimura, S., Kawade, K., Tanaka, R., Matsui, A. Neuropediatrics. (2004) [Pubmed]
  21. Lesch-Nyhan variant: dystonia, ataxia, near-normal intelligence, and no self-mutilation. Adler, C.H., Wrabetz, L. Mov. Disord. (1996) [Pubmed]
  22. Self-mutilation in a patient with mucolipidosis III. Zammarchi, E., Savelli, A., Donati, M.A., Pasquini, E. Pediatric neurology. (1994) [Pubmed]
  23. Serotonergic function and self-injurious behavior in personality disorder patients. New, A.S., Trestman, R.L., Mitropoulou, V., Benishay, D.S., Coccaro, E., Silverman, J., Siever, L.J. Psychiatry research. (1997) [Pubmed]
  24. Hypoxanthine guanine phosphoribosyltransferase (HGPRT) in Gilles de la Tourette syndrome. Merril, C.R., Leavitt, J., Van Keuren, M.L., Ebert, M.H., Caine, E.D. Neurology (1979) [Pubmed]
  25. Habitual self-mutilation in Japan. Matsumoto, T., Azekawa, T., Yamaguchi, A., Asami, T., Iseki, E. Psychiatry and clinical neurosciences. (2004) [Pubmed]
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