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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Allospecific and virus-specific cytolytic T lymphocytes are restricted to the N or C1 domain of H-2 antigens expressed on L cells after DNA-mediated gene transfer.

In order to identify the site(s) on major histocompatibility molecules recognized by cytolytic T lymphocytes (CTLs), the recognition of H-2 antigens expressed when cloned genes are introduced into mouse L cells by DNA-mediated gene transfer has come under investigation. Recently, recombinant H-2 genes have been constructed in vitro from restriction endonuclease fragments of cloned H-2Dd and H-2Ld genes which exchange the N and C1 external domains (exon shuffling). These hybrid H-2 genes direct the synthesis of hybrid H-2 antigens when introduced into L cells by DNA-mediated gene transfer. These transformed L cells have been used as target cells to achieve a more precise localization of the sites recognized by allospecific and virus-specific CTLs. CTL systems were chosen that allow one to probe allospecific Ld or Dd recognition or virus-restricted Ld or Dd recognition. Using this approach we were able to map essential CTL recognition sites to the N and C1 domains of class 1 molecules.[1]

References

  1. Allospecific and virus-specific cytolytic T lymphocytes are restricted to the N or C1 domain of H-2 antigens expressed on L cells after DNA-mediated gene transfer. Reiss, C.S., Evans, G.A., Margulies, D.H., Seidman, J.G., Burakoff, S.J. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
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