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Gene Review

H1  -  histocompatibility 1

Mus musculus

Synonyms: H-1
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Disease relevance of H1


Psychiatry related information on H1


High impact information on H1


Chemical compound and disease context of H1


Biological context of H1


Anatomical context of H1


Associations of H1 with chemical compounds

  • Furthermore, like the intact virus, HA of the H2 (but not H3) subtype is mitogenic only for B cells expressing the class II major histocompatibility complex glycoprotein I-E [29].
  • Retardation of development including immunogenic expression of histocompatibility antigens in mice--by postnatal administration of antiandrogenic steroid [30].
  • These results suggest that other changes in serine/threonine protein phosphorylation besides those involved in activation of cdc2 as a histone H1 kinase may be necessary for proper G2-M transition [31].
  • Comparison of the deduced 120-amino acid sequence from the N terminus of H1 with known protein sequences revealed substantial sequence similarity with the beta chain of the murine fourth complement component C4 and with the related third and fifth complement molecules C5 and C3 and the major histocompatibility complex-encoded sex-limited protein [32].
  • Assignment was accomplished by mutagenically "tagging" the genes by incorporation of a codon for methionine, which is not found in the major somatic H1 variants [33].

Physical interactions of H1


Enzymatic interactions of H1


Regulatory relationships of H1


Other interactions of H1


Analytical, diagnostic and therapeutic context of H1

  • Total PAR of cellular proteins and of histone H1 protein were monitored by slot and Western blot immunoprobe assays, respectively [47].
  • An immunodominant minor histocompatibility alloantigen that initiates corneal allograft rejection [48].
  • Nevertheless, microinjection of phosducin, a protein that binds tightly to free G protein beta gamma subunits, specifically inhibited second polar body emission, the fertilization evoked decrease of H1 kinase activity and pronucleus formation [49].
  • As detected using immunocytochemistry, somatic H1 was present in the nuclei of oocytes of 18-day embryos [50].
  • Species-specific tryptic phosphopeptides were resolved from purified H1 histones using high voltage paper electrophoresis [51].


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  2. Influenza viruses as lymphocyte mitogens. I. B cell mitogenesis by influenza A viruses of the H2 and H6 subtypes is controlled by the I-E/C subregion of the major histocompatibility complex. Scalzo, A.A., Anders, E.M. J. Immunol. (1985) [Pubmed]
  3. Genetic control and fine specificity of the immune response to a synthetic peptide of influenza virus hemagglutinin. Brown, L.E., Murray, J.M., Anders, E.M., Tang, X.L., White, D.O., Tregear, G.W., Jackson, D.C. J. Virol. (1988) [Pubmed]
  4. Rapid induction of polyadenylated H1 histone mRNAs in mouse erythroleukemia cells is regulated by c-myc. Cheng, G.H., Skoultchi, A.I. Mol. Cell. Biol. (1989) [Pubmed]
  5. The dual-specificity phosphatase encoded by vaccinia virus, VH1, is essential for viral transcription in vivo and in vitro. Liu, K., Lemon, B., Traktman, P. J. Virol. (1995) [Pubmed]
  6. Increased locomotor activity, increased food and water intake and decreased PVN neurons in H1 calponin gene-deficient mice. Bannai, M., Yoshimoto, R., MiTSUI-SAITO, M., Hori, M., Nishihara, M., Takahashi, K., Yamamura, H., Taniguchi, S., Katsuki, M., Ozaki, H., Karaki, H. J. Vet. Med. Sci. (2003) [Pubmed]
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  10. Absence of HLA association or linkage for variations in sensitivity to the odor of androstenone. Pollack, M.S., Wysocki, C.J., Beauchamp, G.K., Braun, D., Callaway, C., Dupont, B. Immunogenetics (1982) [Pubmed]
  11. Positive and negative selection of T cells. Starr, T.K., Jameson, S.C., Hogquist, K.A. Annu. Rev. Immunol. (2003) [Pubmed]
  12. The immunological synapse. Bromley, S.K., Burack, W.R., Johnson, K.G., Somersalo, K., Sims, T.N., Sumen, C., Davis, M.M., Shaw, A.S., Allen, P.M., Dustin, M.L. Annu. Rev. Immunol. (2001) [Pubmed]
  13. Discovering the role of the major histocompatibility complex in the immune response. McDevitt, H.O. Annu. Rev. Immunol. (2000) [Pubmed]
  14. H2-M3, a full-service class Ib histocompatibility antigen. Lindahl, K.F., Byers, D.E., Dabhi, V.M., Hovik, R., Jones, E.P., Smith, G.P., Wang, C.R., Xiao, H., Yoshino, M. Annu. Rev. Immunol. (1997) [Pubmed]
  15. The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloning. Simpson, E., Scott, D., Chandler, P. Annu. Rev. Immunol. (1997) [Pubmed]
  16. In nondividing cells, histone H1(0) is synthesized and deposited onto chromatin without accompanying phosphorylation. Hall, J.M., Cole, R.D. Biochemistry (1986) [Pubmed]
  17. Purification and characterization of a specific histone H1 protein kinase from mouse plasmacytoma. Quirin-Stricker, C., Schmitt, M. Eur. J. Biochem. (1981) [Pubmed]
  18. The alkylating agent, dimethyl sulphate, stimulates ADP-ribosylation of histone H1 and other proteins in permeabilised mouse lymphoma (L1210) cells. Thi Man, N., Shall, S. Eur. J. Biochem. (1982) [Pubmed]
  19. Bystander activation of cytotoxic T cells: studies on the mechanism and evaluation of in vivo significance in a transgenic mouse model. Ehl, S., Hombach, J., Aichele, P., Hengartner, H., Zinkernagel, R.M. J. Exp. Med. (1997) [Pubmed]
  20. Soluble factors in tolerance and contact sensitivity to 2,4-dinitrofluorobenzene in mice. III. Histocompatibility antigens associated with the hapten dinitrophenol serve as target molecules on 2,4-dinitrofluorobenzene-immune T cells for soluble suppressor factor. Moorhead, J.W. J. Exp. Med. (1979) [Pubmed]
  21. Isolation and characterization of a mouse fully replication-dependent H1 gene within a genomic cluster of core histone genes. Yang, Y.S., Brown, D.T., Wellman, S.E., Sittman, D.B. J. Biol. Chem. (1987) [Pubmed]
  22. Restricted recognition of beta 2-microglobulin by cytotoxic T lymphocytes. Rammensee, H.G., Robinson, P.J., Crisanti, A., Bevan, M.J. Nature (1986) [Pubmed]
  23. The functional basis of minor histocompatibility loci. Roopenian, D.C., Davis, A.P., Christianson, G.J., Mobraaten, L.E. J. Immunol. (1993) [Pubmed]
  24. Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors. Dai, H., Kaneko, K., Kato, H., Fujii, S., Jing, Y., Xu, A., Sakurai, E., Kato, M., Okamura, N., Kuramasu, A., Yanai, K. Neurosci. Res. (2007) [Pubmed]
  25. Positional cloning and molecular characterization of an immunodominant cytotoxic determinant of the mouse H3 minor histocompatibility complex. Zuberi, A.R., Christianson, G.J., Mendoza, L.M., Shastri, N., Roopenian, D.C. Immunity (1998) [Pubmed]
  26. Association of endogenous viral loci with genes encoding murine histocompatibility and lymphocyte differentiation antigens. Meruelo, D., Rossomando, A., Offer, M., Buxbaum, J., Pellicer, A. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  27. Expression screening of a yeast artificial chromosome contig refines the location of the mouse H3a minor histocompatibility antigen gene. Zuberi, A.R., Christianson, G.J., Dave, S.B., Bradley, J.A., Roopenian, D.C. J. Immunol. (1998) [Pubmed]
  28. T cell subsets required for in vivo and in vitro responses to single and multiple minor histocompatibility antigens. Wettstein, P.J., Korngold, R. Transplantation (1992) [Pubmed]
  29. Direct role of viral hemagglutinin in B-cell mitogenesis by influenza viruses. Poumbourios, P., Anders, E.M., Scalzo, A.A., White, D.O., Hampson, A.W., Jackson, D.C. J. Virol. (1987) [Pubmed]
  30. Retardation of development including immunogenic expression of histocompatibility antigens in mice--by postnatal administration of antiandrogenic steroid. Polácková, M., Viklický, V., Vojtísková, M. Folia Biol. (Praha) (1975) [Pubmed]
  31. Expression of a constitutive form of calcium/calmodulin dependent protein kinase II leads to arrest of the cell cycle in G2. Planas-Silva, M.D., Means, A.R. EMBO J. (1992) [Pubmed]
  32. Hagfish humoral defense protein exhibits structural and functional homology with mammalian complement components. Hanley, P.J., Hook, J.W., Raftos, D.A., Gooley, A.A., Trent, R., Raison, R.L. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  33. Identification through overexpression and tagging of the variant type of the mouse H1e and H1c genes. Brown, D.T., Sittman, D.B. J. Biol. Chem. (1993) [Pubmed]
  34. A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains. Steinmetz, M., Moore, K.W., Frelinger, J.G., Sher, B.T., Shen, F.W., Boyse, E.A., Hood, L. Cell (1981) [Pubmed]
  35. Role of Na+/H+ exchange by interferon-gamma in enhanced expression of JE and I-A beta genes. Prpic, V., Yu, S.F., Figueiredo, F., Hollenbach, P.W., Gawdi, G., Herman, B., Uhing, R.J., Adams, D.O. Science (1989) [Pubmed]
  36. CTLA-4 ligands are required to induce an in vivo interleukin 4 response to a gastrointestinal nematode parasite. Lu, P., Zhou, X., Chen, S.J., Moorman, M., Morris, S.C., Finkelman, F.D., Linsley, P., Urban, J.F., Gause, W.C. J. Exp. Med. (1994) [Pubmed]
  37. Selective abrogation of major histocompatibility complex class II expression on extrahematopoietic cells in mice lacking promoter IV of the class II transactivator gene. Waldburger, J.M., Suter, T., Fontana, A., Acha-Orbea, H., Reith, W. J. Exp. Med. (2001) [Pubmed]
  38. Homologies between cell interaction molecular controlled by major histocompatibility complex- and Igh-V-linked genes that T cells use for communication. Tandem "adaptive" differentiation of producer and acceptor cells. Flood, P., Yamauchi, K., Singer, A., Gershon, R.K. J. Exp. Med. (1982) [Pubmed]
  39. Class I histocompatibility molecule association with phosphorylated calnexin. Implications for rates of intracellular transport. Capps, G.G., Zúñiga, M.C. J. Biol. Chem. (1994) [Pubmed]
  40. Activation of the mitogen-activated protein kinase ERK1 during meiotic progression of mouse pachytene spermatocytes. Sette, C., Barchi, M., Bianchini, A., Conti, M., Rossi, P., Geremia, R. J. Biol. Chem. (1999) [Pubmed]
  41. A mutant E2F-1 transcription factor that affects the phenotype of NIH3T3 fibroblasts inefficiency associates with cyclin A-cdk2. Jordan-Sciutto, K.L., Hall, D.J. Biochem. Cell Biol. (1998) [Pubmed]
  42. Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1. Ohara, J., Paul, W.E. Nature (1985) [Pubmed]
  43. Murine cytomegalovirus inhibits interferon gamma-induced antigen presentation to CD4 T cells by macrophages via regulation of expression of major histocompatibility complex class II-associated genes. Heise, M.T., Connick, M., Virgin, H.W. J. Exp. Med. (1998) [Pubmed]
  44. Genetic variation at a locus (TAM-1) for submaxillary gland protease in the mouse and its location on chromosome No. 7. Skow, L.C. Genetics (1978) [Pubmed]
  45. Ly-m11: the H-3 region of mouse chromosome 2 controls a new surface alloantigen. Tada, N., Kimura, S., Hatzfeld, A., Hämmerling, U. Immunogenetics (1980) [Pubmed]
  46. Complexity of minor histocompatibility loci. Click, R.E. Hum. Immunol. (1985) [Pubmed]
  47. In Vivo Exposure of Swiss Albino Mice to Chronic Low Dose of Dimethylnitrosamine (DMN) Lowers Poly-ADP-Ribosylation (PAR) of Bone Marrow Cell and Blood Lymphocyte Proteins. Kma, L., Sharan, R.N. Mol. Cell. Biochem. (2006) [Pubmed]
  48. An immunodominant minor histocompatibility alloantigen that initiates corneal allograft rejection. Haskova, Z., Sproule, T.J., Roopenian, D.C., Ksander, A.B. Transplantation (2003) [Pubmed]
  49. Roles of heterotrimeric and monomeric G proteins in sperm-induced activation of mouse eggs. Moore, G.D., Ayabe, T., Visconti, P.E., Schultz, R.M., Kopf, G.S. Development (1994) [Pubmed]
  50. Chromatin modifications during oogenesis in the mouse: removal of somatic subtypes of histone H1 from oocyte chromatin occurs post-natally through a post-transcriptional mechanism. Clarke, H.J., Bustin, M., Oblin, C. J. Cell. Sci. (1997) [Pubmed]
  51. Relationship between H1 histone phosphorylation and genome replication in a mouse-Chinese hamster somatic cell hybrid. Hohmann, P.G., He, D.X., Shows, T.B. Exp. Cell Res. (1983) [Pubmed]
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