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Urist, M.R. et al.

Bone cell differentiation and growth factors.

Bone morphogenetic protein and bone-derived growth factors are biochemical tools for research on induced cell differentiation and local mechanisms controlling cell proliferation. Bone morphogenetic protein irreversibly induces differentiation of perivascular mesenchymal-type cells into osteoprogenitor cells. Bone-derived growth factors are secreted by and for osteoprogenitor cells and stimulate DNA synthesis. Bone generation and regeneration are attributable to the co-efficiency of bone morphogenetic protein and bone-derived growth factors.[1]

References

Bone cell differentiation and growth factors. Urist, M.R., DeLange, R.J., Finerman, G.A. Science (1983) [Pubmed]

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