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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Depletion of intracellular polyamines may alter DNA conformation in 9L rat brain tumor cells.

Depletion of polyamines in 9L rat brain tumor cells by treatment with alpha-difluoromethylornithine dramatically altered DNA conformation as measured by viscoelastometry. The reduction of intracellular putrescine and spermidine concentrations to less than 5 percent of their concentrations in control cells decreased the sensitivity of 9L cell DNA to x-irradiation and increased the maximum viscoelastic retardation time of the DNA. Both of these phenomena were reversed by addition of exogenous putrescine.[1]

References

  1. Depletion of intracellular polyamines may alter DNA conformation in 9L rat brain tumor cells. Hung, D.T., Marton, L.J., Deen, D.F., Shafer, R.H. Science (1983) [Pubmed]
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