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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Methapyrilene is inactive in the hepatocyte-mediated Chinese hamster ovary/hypoxanthine-guanine phosphoribosyl transferase mutational assay.

Methapyrilene, tested at both non-hepatocytotoxic and hepatocytotoxic concentrations, failed to induce somatic mutations in the hepatocyte-mediated Chinese hamster ovary/hypoxanthine-guanine phosphoribosyl transferase (HGPRT) mutational assay. These data support the conclusion that methapyrilene induces the carcinogenesis process through a non-DNA damaging mechanism, suggested when this antihistamine previously failed to induce a genotoxic response in several in vitro test systems developed to detect carcinogens and mutagens.[1]

References

  1. Methapyrilene is inactive in the hepatocyte-mediated Chinese hamster ovary/hypoxanthine-guanine phosphoribosyl transferase mutational assay. Casciano, D.A., Schol, H.M. Cancer Lett. (1984) [Pubmed]
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