The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Restryl     N',N'-dimethyl-N-pyridin-2- yl-N-(thiophen...

Synonyms: Histadryl, Histase, Lulamin, Semikon, Tenalin, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Thenylpyramine


High impact information on Thenylpyramine


Chemical compound and disease context of Thenylpyramine


Biological context of Thenylpyramine


Anatomical context of Thenylpyramine


Associations of Thenylpyramine with other chemical compounds


Gene context of Thenylpyramine


Analytical, diagnostic and therapeutic context of Thenylpyramine


  1. A sequential study of methapyrilene hydrochloride-induced liver carcinogenesis in male F344 rats. Ohshima, M., Ward, J.M., Brennan, L.M., Creasia, D.A. J. Natl. Cancer Inst. (1984) [Pubmed]
  2. Carcinogenesis by nonmutagenic chemicals: early response of rat liver cells induced by methapyrilene. Iype, P.T., Bucana, C.D., Kelley, S.P. Cancer Res. (1985) [Pubmed]
  3. Examination of genotoxicity, toxicity and morphologic alterations in hepatocytes following in vivo or in vitro exposure to methapyrilene. Steinmetz, K.L., Tyson, C.K., Meierhenry, E.F., Spalding, J.W., Mirsalis, J.C. Carcinogenesis (1988) [Pubmed]
  4. S-adenosylmethionine, S-adenosylhomocysteine and DNA methylation levels in the liver of rats fed methapyrilene and analogs. Hernandez, L., Allen, P.T., Poirier, L.A., Lijinsky, W. Carcinogenesis (1989) [Pubmed]
  5. Weak and unexpected mutagenicity to Salmonella of the rat hepatocarcinogen methapyrilene. Ashby, J., Callander, R.D., Paton, D., Zeiger, E., Ratpan, F. Environ. Mol. Mutagen. (1988) [Pubmed]
  6. Liver tumors induced in rats by oral administration of the antihistaminic methapyrilene hydrochloride. Lijinsky, W., Reuber, M.D., Blackwell, B.N. Science (1980) [Pubmed]
  7. Inability of methapyrilene to induce sister chromatid exchanges in vitro and in vivo. Iype, P.T., Ray-Chaudhuri, R., Lijinsky, W., Kelley, S.P. Cancer Res. (1982) [Pubmed]
  8. Mutation spectrum of a binary mixture of mutagens (methapyrilene and sodium azide) in strain TA1535 of Salmonella. Shelton, M.L., Ashby, J., DeMarini, D.M. Mutat. Res. (1994) [Pubmed]
  9. Mutagenicity studies of selected antihistamines, their metabolites and products of nitrosation. Kammerer, R.C., Froines, J.R., Price, T. Food Chem. Toxicol. (1986) [Pubmed]
  10. Methapyrilene kinetics and dynamics. Calandre, E.P., Alferez, N., Hassanein, K., Azarnoff, D.L. Clin. Pharmacol. Ther. (1981) [Pubmed]
  11. Methapyrilene induces membrane lipid peroxidation of rat liver cells. Perera, M.I., Katyal, S.L., Shinozuka, H. Carcinogenesis (1985) [Pubmed]
  12. Trapping of metabolically generated electrophilic species with cyanide ion: metabolism of methapyrilene. Ziegler, R., Ho, B., Castagnoli, N. J. Med. Chem. (1981) [Pubmed]
  13. Distribution of the liver carcinogen methapyrilene in Fischer rats and its interaction with macromolecules. Lijinsky, W., Muschik, G.M. J. Cancer Res. Clin. Oncol. (1982) [Pubmed]
  14. Morphology of early changes in liver carcinogenesis induced by methapyrilene. Reznik-Schüller, H.M., Lijinsky, W. Arch. Toxicol. (1981) [Pubmed]
  15. Methapyrilene hepatotoxicity is associated with increased hepatic glutathione, the formation of glucuronide conjugates, and enterohepatic recirculation. Ratra, G.S., Powell, C.J., Park, B.K., Maggs, J.L., Cottrell, S. Chem. Biol. Interact. (2000) [Pubmed]
  16. The hepatocarcinogen methapyrilene but not the analog pyrilamine induces sustained hepatocellular replication and protein alterations in F344 rats in a 13-week feed study. Cunningham, M.L., Pippin, L.L., Anderson, N.L., Wenk, M.L. Toxicol. Appl. Pharmacol. (1995) [Pubmed]
  17. In vitro nitrosation of methapyrilene. Mergens, W.J., Vane, F.M., Tannenbaum, S.R., Green, L., Skipper, P.L. Journal of pharmaceutical sciences. (1979) [Pubmed]
  18. Fast-atom bombardment and thermospray mass spectrometry for the characterization of two glucuronide metabolites of methapyrilene. Lay, J.O., Getek, T.A., Kelly, D.W., Slikker, W., Korfmacher, W.A. Rapid Commun. Mass Spectrom. (1989) [Pubmed]
  19. Principal component analysis of mass spectra of peptides generated from the tryptic digestion of protein mixtures. Bryant, D.K., Monté, S., Man, W.J., Kramer, K., Bugelski, P., Neville, W., White, I.R., Camilleri, P. Rapid Commun. Mass Spectrom. (2001) [Pubmed]
  20. Involvement of lipoxygenase products in myometrial contractions. Carraher, R., Hahn, D.W., Ritchie, D.M., McGuire, J.L. Prostaglandins (1983) [Pubmed]
  21. Quantitative PCR deconstruction of discrepancies between results reported by different hybridization platforms. Goodsaid, F.M., Smith, R.J., Rosenblum, I.Y. Environ. Health Perspect. (2004) [Pubmed]
  22. Altered distribution of hexokinase and glucokinase between parenchymal and nonparenchymal cells of rat liver after methapyrilene intoxication. Fischer, W., Wagle, S.R., Katz, N.R. Biochem. Biophys. Res. Commun. (1983) [Pubmed]
  23. The potent hepatocarcinogen methapyrilene induces mutations in L5178Y mouse lymphoma cells in the apparent absence of DNA adduct formation. Casciano, D.A., Talaska, G., Clive, D. Mutat. Res. (1991) [Pubmed]
  24. Methapyrilene is inactive in the hepatocyte-mediated Chinese hamster ovary/hypoxanthine-guanine phosphoribosyl transferase mutational assay. Casciano, D.A., Schol, H.M. Cancer Lett. (1984) [Pubmed]
  25. Sequential morphologic changes during methapyrilene-induced hepatocellular carcinogenesis in rats. Reznik-Schüller, H.M., Gregg, M. J. Natl. Cancer Inst. (1983) [Pubmed]
  26. Dose-responses in rat hepatic protein modification and expression following exposure to the rat hepatocarcinogen methapyrilene. Richardson, F.C., Horn, D.M., Anderson, N.L. Carcinogenesis (1994) [Pubmed]
  27. Plasma elimination and urinary excretion of methapyrilene in the rat. Kelly, D.W., Holder, C.L., Korfmacher, W.A., Slikker, W. Drug Metab. Dispos. (1990) [Pubmed]
  28. Plasma and urine concentrations of methapyrilene by nitrogen-phosphorus gas-liquid chromatography. Baselt, R.C., Franch, S. J. Chromatogr. (1980) [Pubmed]
  29. Methapyrilene is a genotoxic carcinogen: studies on methapyrilene and pyrilamine in the L5178Y/TK +/- mouse lymphoma assay. Turner, N.T., Woolley, J.L., Hozier, J.C., Sawyer, J.R., Clive, D. Mutat. Res. (1987) [Pubmed]
WikiGenes - Universities