Gene Review:
Hprt1 - hypoxanthine phosphoribosyltransferase 1
Rattus norvegicus
Synonyms:
HGPRT, HGPRTase, Hgprtase, Hprt, Hypoxanthine-guanine phosphoribosyltransferase
Chen,
Mittelstaedt,
Heflich,
Manjanatha,
Shelton,
Aidoo,
Lyn-Cook,
Casciano,
Yadollahi-Farsani,
Davies,
Boobis,
Inoue,
Kimura,
Tuji,
Chen,
Aidoo,
Manjanatha,
Mittelstaedt,
Shelton,
Lyn-Cook,
Casciano,
Heflich,
Mittelstaedt,
Smith,
Chen,
Beland,
Heflich,
- The biochemical basis of the behavioral disorder in the Lesch-Nyhan syndrome. Baumeister, A.A., Frye, G.D. Neuroscience and biobehavioral reviews. (1985)
- Dopamine metabolism in hypoxanthine-guanine phosphoribosyltransferase-deficient variants of PC12 cells. Bitler, C.M., Howard, B.D. J. Neurochem. (1986)
- Characterization of the alterations in purine nucleotide metabolism in hypoxanthine-guanine phosphoribosyltransferase-deficient rat neuroma cell line. Zoref-Shani, E., Bromberg, Y., Brosh, S., Sidi, Y., Sperling, O. J. Neurochem. (1993)
- Lesch-Nyhan syndrome, caffeine model: increase of purine and pyrimidine enzymes in rat brain. Miñana, M.D., Portolés, M., Jordá, A., Grisolía, S. J. Neurochem. (1984)
- Production of long term steroid-producing granulosa cell cultures by cell hybridization. Zeleznik, A.J., Hillier, S.G., Knazek, R.A., Ross, G.T., Coon, H.G. Endocrinology (1979)
- Tissue-specific gene expression results from a purine- and pyrimidine-free diet and 6-mercaptopurine in the rat small intestine and colon. Leleiko, N.S., Martin, B.A., Walsh, M., Kazlow, P., Rabinowitz, S., Sterling, K. Gastroenterology (1987)
- Mutagenesis induced by procarcinogens at the hypoxanthine-guanine phosphoribosyl transferase locus of human fibroblasts cocultured with rat hepatocytes. Michalopoulos, G., Strom, S.C., Kligerman, A.D., Irons, G.P., Novicki, D.L. Cancer Res. (1981)
- Adenine nucleotide metabolism in hearts of diabetic rats. Comparison to diaphragm, liver, and kidney. Jenkins, R.L., McDaniel, H.G., Digerness, S., Parrish, S.W., Ong, R.L. Diabetes (1988)
- Rat and hamster hepatocyte-mediated induction of SCEs and mutation in V79 cells and mutation of salmonella by aminofluorene and dimethylnitrosamine. Langenbach, R., Leavitt, S., Hix, C., Sharief, Y., Allen, J.W. Mutat. Res. (1986)
- Lack of activity of the bacterial mutagen emodin in HGPRT and SCE assay with V79 Chinese hamster cells. Bruggeman, I.M., van der Hoeven, J.C. Mutat. Res. (1984)
- Mutagenic studies on the hair dye 2-(2',4'-diaminophenoxy)ethanol with different genetic systems. Loprieno, N., Barale, R., Mariani, L., Zaccaro, L. Mutat. Res. (1982)
- Single nucleotide instability: a wide involvement in human and rat mammary carcinogenesis? Okochi, E., Watanabe, N., Sugimura, T., Ushijima, T. Mutat. Res. (2002)
- Toxicity studies of butylated hydroxyanisole and butylated hydroxytoluene. I. Genetic and cellular effects. Williams, G.M., McQueen, C.A., Tong, C. Food Chem. Toxicol. (1990)
- DNA sequence flanking the protein coding regions of the rat Hprt gene. Chen, T., Mittelstaedt, R.A., Heflich, R.H. Mutat. Res. (1998)
- The gene encoding hypoxanthine-guanine phosphoribosyltransferase as target for mutational analysis: PCR cloning and sequencing of the cDNA from the rat. Jansen, J.G., Vrieling, H., van Zeeland, A.A., Mohn, G.R. Mutat. Res. (1992)
- Hprt mutant frequency and molecular analysis of Hprt mutations in Fischer 344 rats treated with thiotepa. Chen, T., Aidoo, A., Mittelstaedt, R.A., Casciano, D.A., Heflich, R.H. Carcinogenesis (1999)
- Comparison of in vivo mutagenesis in the endogenous Hprt gene and the lacI transgene of Big Blue(R) rats treated with 7, 12-dimethylbenz[a]anthracene. Manjanatha, M.G., Shelton, S.D., Aidoo, A., Lyn-Cook, L.E., Casciano, D.A. Mutat. Res. (1998)
- Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue rats. Chen, T., Aidoo, A., Manjanatha, M.G., Mittelstaedt, R.A., Shelton, S.D., Lyn-Cook, L.E., Casciano, D.A., Heflich, R.H. Mutat. Res. (1998)
- Analysis of mutations and bone marrow micronuclei in Big Blue rats fed leucomalachite green. Manjanatha, M.G., Shelton, S.D., Bishop, M., Shaddock, J.G., Dobrovolsky, V.N., Heflich, R.H., Webb, P.J., Blankenship, L.R., Beland, F.A., Greenlees, K.J., Culp, S.J. Mutat. Res. (2004)
- Analysis of in vivo mutation in exon 8 of the rat hprt gene. Mittelstaedt, R.A., Heflich, R.H. Mutat. Res. (1994)
- DNA adduct formation and mutant induction in Sprague-Dawley rats treated with tamoxifen and its derivatives. da Costa, G.G., McDaniel-Hamilton, L.P., Heflich, R.H., Marques, M.M., Beland, F.A. Carcinogenesis (2001)
- Comparison of the mutagenic potency of 1,3-butadiene at the hprt locus of T-lymphocytes following inhalation exposure of female B6C3F1 mice and F344 rats. Meng, Q., Recio, L., Reilly, A.A., Wong, B.A., Bauer, M., Walker, V.E. Carcinogenesis (1998)
- The mutational signature of alpha-hydroxytamoxifen at Hprt locus in Chinese hamster cells. Yadollahi-Farsani, M., Davies, D.S., Boobis, A.R. Carcinogenesis (2002)
- Effects of particle exposure and particle-elicited inflammatory cells on mutation in rat alveolar epithelial cells. Driscoll, K.E., Deyo, L.C., Carter, J.M., Howard, B.W., Hassenbein, D.G., Bertram, T.A. Carcinogenesis (1997)
- Sequence specificity of Hprt lymphocyte mutation in rats fed the hepatocarcinogen 2-acetylaminofluorene. Mittelstaedt, R.A., Smith, B.A., Chen, T., Beland, F.A., Heflich, R.H. Mutat. Res. (1999)
- Prostaglandin A2 specifically represses insulin-like growth factor-I gene expression in C6 rat glioma cells. Bui, T., Kuo, C., Rotwein, P., Straus, D.S. Endocrinology (1997)
- Guanosine metabolism in adult rat cardiac myocytes: inhibition by acyclovir and analysis of a metabolic pathway. Geisbuhler, T.P., Schwager, T.L., Rovetto, M.J. J. Mol. Cell. Cardiol. (1992)
- Effect of undernutrition on some enzymes involved in the salvage pathway of purine nucleotides in different regions of developing rat brain. Vanella, A., Barcellona, M.L., Serra, I., Ragusa, N., Avola, R., Avitabile, M., Giuffrida, A.M. Neurochem. Res. (1983)
- Degradation profile of mRNA in a dead rat body: basic semi-quantification study. Inoue, H., Kimura, A., Tuji, T. Forensic Sci. Int. (2002)
- Mutagenicity of 1,3-butadiene at the Hprt locus of T-lymphocytes following inhalation exposures of female mice and rats. Meng, Q., Henderson, R.F., Chen, T., Heflich, R.H., Walker, D.M., Bauer, M.J., Reilly, A.A., Walker, V.E. Mutat. Res. (1999)
- IMP dehydrogenase from the intracellular parasitic protozoan Eimeria tenella and its inhibition by mycophenolic acid. Hupe, D.J., Azzolina, B.A., Behrens, N.D. J. Biol. Chem. (1986)
- Dual role of hypoxanthine in the reoxygenation of hypoxic isolated rat hearts. Tarantola, M., Motterlini, R., Beretta, M., Samaja, M. J. Mol. Cell. Cardiol. (1991)