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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Importance of sites of tracer administration and blood sampling in relation to leucine metabolism. Practical considerations.

For the same infusion site of L-[1-14C]leucine, sampling downstream of arterial blood underestimates leucine turnover, whereas sampling of venous blood overestimates turnover. Further, the lungs release a small but consistent amount of leucine into the blood. Unlabelled leucine also is produced by the portal-drained viscera, and some is removed immediately by the liver. These sources of leucine should thus be considered in turnover calculations.[1]

References

  1. Importance of sites of tracer administration and blood sampling in relation to leucine metabolism. Practical considerations. Pell, J.M., Caldarone, E.M., Bergman, E.N. Biochem. J. (1983) [Pubmed]
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