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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

The preoperative use of cimetidine as a means of preventing symptomatic hypocalcemia following a parathyroid operation.

Cimetidine has been shown to lower circulating PTH levels effectively by causing an intraglandular rearrangement of PTH peptides in human parathyroid tissue in instances of primary hyperparathyroidism. A state of "euparathyroidism" is established. It has been statistically found at a 98.7 per cent confidence level that preoperative treatment with cimetidine effectively prevents symptomatic hypocalcemia postoperatively after parathyroid operations. It is anticipated that cimetidine has provided a tool for the in depth exploration of parathyroid disease.[1]

References

  1. The preoperative use of cimetidine as a means of preventing symptomatic hypocalcemia following a parathyroid operation. Sherwood, J.K., Ackroyd, F.W., Garcia, M., Willis, I.H., Minervini, D., Seiden, E.F. Surgery, gynecology & obstetrics. (1983) [Pubmed]
 
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