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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Congenital sensorineural hearing loss.

The ears of 47 selected patients with congenital sensorineural hearing loss were examined with complex-motion tomography. The patients were divided into 3 general categories: those with a recognized syndrome, those with sensorineural hearing loss unrelated to any known syndrome, and those with microtia. A great variety of inner ear anomalies was detected, but rarely were these characteristic of a particular clinical entity. The most common finding was the Mondini malformation or one of its variants. Isolated dysplasia of the internal auditory canal or the vestibular aqueduct may be responsible for sensorineural hearing loss in some patients. Patients with microtia may also have severe inner ear abnormalities despite the fact that the outer and inner ears develop embryologically from completely separate systems.[1]


  1. Congenital sensorineural hearing loss. Mafee, M.F., Selis, J.E., Yannias, D.A., Valvassori, G.E., Pruzansky, S., Applebaum, E.L., Capek, V. Radiology. (1984) [Pubmed]
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