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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Munchausen syndrome, depression, and the dexamethasone suppression test.

The authors describe two patients with Munchausen syndrome who met DSM-III criteria for major depression. Both patients exhibited evidence of nonsuppression of serum cortisol by dexamethasone. Although many patients with Munchausen syndrome have been reported to be depressed, only a few have received a diagnosis of major depression. Because the physical and psychiatric symptoms of the Munchausen patient are so complex, clinical assessment may stop at a diagnosis of Munchausen syndrome, and major depression may be overlooked. A diagnosis of major depression should be considered in the evaluation of these patients; the dexamethasone suppression test may enhance clinical assessment.[1]


  1. Munchausen syndrome, depression, and the dexamethasone suppression test. Evans, D.L., Hsiao, J.K., Nemeroff, C.B. The American journal of psychiatry. (1984) [Pubmed]
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